Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma
Abstract Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissues (glands and stroma) located outside the uterine cavity. The pathophysiology of this condition remains incompletely understood. Local bleeding and inflammation within endometriosis lesio...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-85017-4 |
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| author | Rina Nulianti Hartanto Bayuaji Mulyanusa Amarullah Ritonga Tono Djuwantono Dian Tjahyadi Anita Rachmawati Sri Ratna Dwiningsih Aisyah Shofiatun Nisa Putri Nadhira Adinda Adriansyah |
| author_facet | Rina Nulianti Hartanto Bayuaji Mulyanusa Amarullah Ritonga Tono Djuwantono Dian Tjahyadi Anita Rachmawati Sri Ratna Dwiningsih Aisyah Shofiatun Nisa Putri Nadhira Adinda Adriansyah |
| author_sort | Rina Nulianti |
| collection | DOAJ |
| description | Abstract Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissues (glands and stroma) located outside the uterine cavity. The pathophysiology of this condition remains incompletely understood. Local bleeding and inflammation within endometriosis lesions, which occur in an environment rich in iron, reactive oxygen species (ROS), and free radicals, can disturb the balance of iron within the peritoneal cavity. This disruption can trigger oxidative injury and an inflammatory response, leading to ferroptosis, particularly in the endometrioma phenotype. This research utilized an observational analytical method with a cross-sectional design to examine the relationship between ferritin and GPx4 levels by assessing them simultaneously. The data collection occurred at Dr. Hasan Sadikin Hospital, Cibabat Hospital, Bandung Kiwari Hospital, and Limijati Women and Children Hospital Bandung. Observational analytic data were gathered between February and July 2023 from female patients diagnosed with endometrioma who underwent either laparoscopic or laparotomy surgery, either for therapeutic or diagnostic reasons. There were 58 patients who met the inclusion and exclusion criteria in this study. A significant correlation was observed between ferritin and glutathione peroxidase 4 (GPx4) levels with a correlation coefficient of -0.600 (p < 0.001). However, there was no significant correlation between both ferritin levels and the severity of endometriosis (based on Association of Gynecologic Laparoscopists staging). There was significant correlation between ferritin and glutathione peroxidase 4 (GPx4) levels. |
| format | Article |
| id | doaj-art-6062a20a78b04ed9955dc422725e3002 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-6062a20a78b04ed9955dc422725e30022025-02-09T12:36:04ZengNature PortfolioScientific Reports2045-23222025-02-011511710.1038/s41598-024-85017-4Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometriomaRina Nulianti0Hartanto Bayuaji1Mulyanusa Amarullah Ritonga2Tono Djuwantono3Dian Tjahyadi4Anita Rachmawati5Sri Ratna Dwiningsih6Aisyah Shofiatun Nisa7Putri Nadhira Adinda Adriansyah8Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General HospitalDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General HospitalDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General HospitalDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General HospitalDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General HospitalDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General HospitalDepartment of Obstetrics and Gynecology, Faculty of Medicine, Dr. Sutomo General Hospital, Universitas AirlanggaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General HospitalDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General HospitalAbstract Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissues (glands and stroma) located outside the uterine cavity. The pathophysiology of this condition remains incompletely understood. Local bleeding and inflammation within endometriosis lesions, which occur in an environment rich in iron, reactive oxygen species (ROS), and free radicals, can disturb the balance of iron within the peritoneal cavity. This disruption can trigger oxidative injury and an inflammatory response, leading to ferroptosis, particularly in the endometrioma phenotype. This research utilized an observational analytical method with a cross-sectional design to examine the relationship between ferritin and GPx4 levels by assessing them simultaneously. The data collection occurred at Dr. Hasan Sadikin Hospital, Cibabat Hospital, Bandung Kiwari Hospital, and Limijati Women and Children Hospital Bandung. Observational analytic data were gathered between February and July 2023 from female patients diagnosed with endometrioma who underwent either laparoscopic or laparotomy surgery, either for therapeutic or diagnostic reasons. There were 58 patients who met the inclusion and exclusion criteria in this study. A significant correlation was observed between ferritin and glutathione peroxidase 4 (GPx4) levels with a correlation coefficient of -0.600 (p < 0.001). However, there was no significant correlation between both ferritin levels and the severity of endometriosis (based on Association of Gynecologic Laparoscopists staging). There was significant correlation between ferritin and glutathione peroxidase 4 (GPx4) levels.https://doi.org/10.1038/s41598-024-85017-4EndometriomaFerritinGlutathione peroxidase 4 (GPx4) |
| spellingShingle | Rina Nulianti Hartanto Bayuaji Mulyanusa Amarullah Ritonga Tono Djuwantono Dian Tjahyadi Anita Rachmawati Sri Ratna Dwiningsih Aisyah Shofiatun Nisa Putri Nadhira Adinda Adriansyah Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma Scientific Reports Endometrioma Ferritin Glutathione peroxidase 4 (GPx4) |
| title | Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma |
| title_full | Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma |
| title_fullStr | Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma |
| title_full_unstemmed | Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma |
| title_short | Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma |
| title_sort | correlation of ferritin and glutathione peroxidase 4 gpx4 level as a marker of ferroptosis process in endometrioma |
| topic | Endometrioma Ferritin Glutathione peroxidase 4 (GPx4) |
| url | https://doi.org/10.1038/s41598-024-85017-4 |
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