Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine.
<h4>Background</h4>DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS.<h4>Aim</h4>The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine...
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Public Library of Science (PLoS)
2017-01-01
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| author | Nienke S van Ditzhuijzen Mie Kurata Mieke van den Heuvel Oana Sorop Richard W B van Duin Ilona Krabbendam-Peters Jurgen Ligthart Karen Witberg Magdalena Murawska Brett Bouma Martin Villiger Hector M Garcia-Garcia Patrick W Serruys Felix Zijlstra Gijs van Soest Dirk-Jan Duncker Evelyn Regar Heleen M M van Beusekom |
| author_facet | Nienke S van Ditzhuijzen Mie Kurata Mieke van den Heuvel Oana Sorop Richard W B van Duin Ilona Krabbendam-Peters Jurgen Ligthart Karen Witberg Magdalena Murawska Brett Bouma Martin Villiger Hector M Garcia-Garcia Patrick W Serruys Felix Zijlstra Gijs van Soest Dirk-Jan Duncker Evelyn Regar Heleen M M van Beusekom |
| author_sort | Nienke S van Ditzhuijzen |
| collection | DOAJ |
| description | <h4>Background</h4>DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS.<h4>Aim</h4>The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine with and without diabetes mellitus fed a 'fast-food' diet (FF-DM and FF-NDM, respectively) by sequential optical coherence tomography (OCT)-imaging and histology.<h4>Methods</h4>Fifteen male swine were evaluated. Eight received streptozotocin-injection to induce DM. After 9 months (M), 32 single BVS were implanted in epicardial arteries with a stent to artery (S/A)-ratio of 1.1:1 under quantitative coronary angiography (QCA) and OCT guidance. Lumen, scaffold, neointimal coverage and composition were assessed by QCA, OCT and near-infrared spectroscopy (NIRS) pre- and/or post-procedure, at 3M and 6M. Additionally, polarization-sensitive (PS)-OCT was performed in 7 swine at 6M. After sacrifice at 3M and 6M, histology and polymer degradation analysis were performed.<h4>Results</h4>Late lumen loss was high (~60%) within the first 3M after BVS-implantation (P<0.01 FF-DM vs. FF-NDM) and stabilized between 3M and 6M (<5% change in FF-DM, ~10% in FF-NDM; P>0.20). Neointimal coverage was highly heterogeneous in all swine (DM vs. NDM P>0.05), with focal lipid accumulation, irregular collagen distribution and neointimal calcification. Likewise, polymer mass loss was low (~2% at 3M, ~5% at 6M;P>0.20) and not associated with DM or inflammation.<h4>Conclusion</h4>Scaffold coverage showed signs of neo-atherosclerosis in all FF-DM and FF-NDM swine, scaffold polymer was preserved and the vascular response to BVS was not influenced by diabetes. |
| format | Article |
| id | doaj-art-605cf802360c459c8b9d60499e4f8e7a |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-605cf802360c459c8b9d60499e4f8e7a2025-08-20T03:04:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018341910.1371/journal.pone.0183419Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine.Nienke S van DitzhuijzenMie KurataMieke van den HeuvelOana SoropRichard W B van DuinIlona Krabbendam-PetersJurgen LigthartKaren WitbergMagdalena MurawskaBrett BoumaMartin VilligerHector M Garcia-GarciaPatrick W SerruysFelix ZijlstraGijs van SoestDirk-Jan DunckerEvelyn RegarHeleen M M van Beusekom<h4>Background</h4>DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS.<h4>Aim</h4>The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine with and without diabetes mellitus fed a 'fast-food' diet (FF-DM and FF-NDM, respectively) by sequential optical coherence tomography (OCT)-imaging and histology.<h4>Methods</h4>Fifteen male swine were evaluated. Eight received streptozotocin-injection to induce DM. After 9 months (M), 32 single BVS were implanted in epicardial arteries with a stent to artery (S/A)-ratio of 1.1:1 under quantitative coronary angiography (QCA) and OCT guidance. Lumen, scaffold, neointimal coverage and composition were assessed by QCA, OCT and near-infrared spectroscopy (NIRS) pre- and/or post-procedure, at 3M and 6M. Additionally, polarization-sensitive (PS)-OCT was performed in 7 swine at 6M. After sacrifice at 3M and 6M, histology and polymer degradation analysis were performed.<h4>Results</h4>Late lumen loss was high (~60%) within the first 3M after BVS-implantation (P<0.01 FF-DM vs. FF-NDM) and stabilized between 3M and 6M (<5% change in FF-DM, ~10% in FF-NDM; P>0.20). Neointimal coverage was highly heterogeneous in all swine (DM vs. NDM P>0.05), with focal lipid accumulation, irregular collagen distribution and neointimal calcification. Likewise, polymer mass loss was low (~2% at 3M, ~5% at 6M;P>0.20) and not associated with DM or inflammation.<h4>Conclusion</h4>Scaffold coverage showed signs of neo-atherosclerosis in all FF-DM and FF-NDM swine, scaffold polymer was preserved and the vascular response to BVS was not influenced by diabetes.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0183419&type=printable |
| spellingShingle | Nienke S van Ditzhuijzen Mie Kurata Mieke van den Heuvel Oana Sorop Richard W B van Duin Ilona Krabbendam-Peters Jurgen Ligthart Karen Witberg Magdalena Murawska Brett Bouma Martin Villiger Hector M Garcia-Garcia Patrick W Serruys Felix Zijlstra Gijs van Soest Dirk-Jan Duncker Evelyn Regar Heleen M M van Beusekom Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine. PLoS ONE |
| title | Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine. |
| title_full | Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine. |
| title_fullStr | Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine. |
| title_full_unstemmed | Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine. |
| title_short | Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine. |
| title_sort | neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non diabetic swine |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0183419&type=printable |
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