Assessing myelofibrosis burden on QoL and productivity from healthcare personnel and patient perspectives in India
Abstract Background Myelofibrosis (MF), leads to variety of symptoms, significantly impacting patients’ quality of life (QoL) and work productivity. Limited data exists on MF in India. This survey conducted among Indian physicians and their patients with MF evaluated patient journey, understand perc...
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| Language: | English |
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BMC
2025-07-01
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| Online Access: | https://doi.org/10.1186/s12885-025-14324-4 |
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| author | Prantar Chakrabarti Abhay Bhave Claire Harrison Tulika Seth Vikram Mathews Disha Shetty |
| author_facet | Prantar Chakrabarti Abhay Bhave Claire Harrison Tulika Seth Vikram Mathews Disha Shetty |
| author_sort | Prantar Chakrabarti |
| collection | DOAJ |
| description | Abstract Background Myelofibrosis (MF), leads to variety of symptoms, significantly impacting patients’ quality of life (QoL) and work productivity. Limited data exists on MF in India. This survey conducted among Indian physicians and their patients with MF evaluated patient journey, understand perceptions around symptom burden, its impact on QoL, and management. Methods This cross-sectional and multicentric survey between October to November 2021 across 17 cities was conducted using a structured questionnaire based on certain identified themes (symptom burden, QoL parameters, treatment goals and patient communication) during one-on-one telephonic interview. Descriptive statistics were used for data analysis. Results Fifty physicians and 154 patients (primary MF: 51, post-PV: 78, post-ET: 25) participated. Diagnostic delay of 10 months from symptom onset was noted. 151 (98%) patients reported reduced QoL and loss of work productivity. Majority of the patients (56%) reported a negative impact on work productivity, with 76% confirming that MF hindered their work-related daily activities and 42% having reduced work hours. Key symptoms included abdominal pain (patients: 81%, physicians: 70%), fatigue (77% vs. 73%), and fever (54% vs. 48%). Patient-physician perception discrepancies on QoL factors were notable, particularly bone pain (12% vs. 64%), sleep difficulties (8% vs. 70%), sexual problems (2% vs. 78%), depression (4% vs. 63%), and inactivity (4% vs. 66%). Conclusion The study results highlight the negative impact of MF on work productivity by hampering their work-related daily activities and reducing the work hours. The findings underscore the significance of enhancing patient-physician communication and standardizing monitoring practices for improving care outcomes. |
| format | Article |
| id | doaj-art-605bb127615b40b799b37e4c2b4d8dc4 |
| institution | DOAJ |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-605bb127615b40b799b37e4c2b4d8dc42025-08-20T03:03:37ZengBMCBMC Cancer1471-24072025-07-0125111110.1186/s12885-025-14324-4Assessing myelofibrosis burden on QoL and productivity from healthcare personnel and patient perspectives in IndiaPrantar Chakrabarti0Abhay Bhave1Claire Harrison2Tulika Seth3Vikram Mathews4Disha Shetty5Zoho CorporationEmpire Centre Haematology & Onocology Speciality ClinicGuy’s and St Thomas’ NHS Foundation TrustAIIMSChristian Medical CollegeFranchise Medical Head- Oncology, Novartis Healthcare Private Limited IndiaAbstract Background Myelofibrosis (MF), leads to variety of symptoms, significantly impacting patients’ quality of life (QoL) and work productivity. Limited data exists on MF in India. This survey conducted among Indian physicians and their patients with MF evaluated patient journey, understand perceptions around symptom burden, its impact on QoL, and management. Methods This cross-sectional and multicentric survey between October to November 2021 across 17 cities was conducted using a structured questionnaire based on certain identified themes (symptom burden, QoL parameters, treatment goals and patient communication) during one-on-one telephonic interview. Descriptive statistics were used for data analysis. Results Fifty physicians and 154 patients (primary MF: 51, post-PV: 78, post-ET: 25) participated. Diagnostic delay of 10 months from symptom onset was noted. 151 (98%) patients reported reduced QoL and loss of work productivity. Majority of the patients (56%) reported a negative impact on work productivity, with 76% confirming that MF hindered their work-related daily activities and 42% having reduced work hours. Key symptoms included abdominal pain (patients: 81%, physicians: 70%), fatigue (77% vs. 73%), and fever (54% vs. 48%). Patient-physician perception discrepancies on QoL factors were notable, particularly bone pain (12% vs. 64%), sleep difficulties (8% vs. 70%), sexual problems (2% vs. 78%), depression (4% vs. 63%), and inactivity (4% vs. 66%). Conclusion The study results highlight the negative impact of MF on work productivity by hampering their work-related daily activities and reducing the work hours. The findings underscore the significance of enhancing patient-physician communication and standardizing monitoring practices for improving care outcomes.https://doi.org/10.1186/s12885-025-14324-4MyelofibrosisMyeloproliferative neoplasmsSymptom burdenQuality of life |
| spellingShingle | Prantar Chakrabarti Abhay Bhave Claire Harrison Tulika Seth Vikram Mathews Disha Shetty Assessing myelofibrosis burden on QoL and productivity from healthcare personnel and patient perspectives in India BMC Cancer Myelofibrosis Myeloproliferative neoplasms Symptom burden Quality of life |
| title | Assessing myelofibrosis burden on QoL and productivity from healthcare personnel and patient perspectives in India |
| title_full | Assessing myelofibrosis burden on QoL and productivity from healthcare personnel and patient perspectives in India |
| title_fullStr | Assessing myelofibrosis burden on QoL and productivity from healthcare personnel and patient perspectives in India |
| title_full_unstemmed | Assessing myelofibrosis burden on QoL and productivity from healthcare personnel and patient perspectives in India |
| title_short | Assessing myelofibrosis burden on QoL and productivity from healthcare personnel and patient perspectives in India |
| title_sort | assessing myelofibrosis burden on qol and productivity from healthcare personnel and patient perspectives in india |
| topic | Myelofibrosis Myeloproliferative neoplasms Symptom burden Quality of life |
| url | https://doi.org/10.1186/s12885-025-14324-4 |
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