Bioequivalence of Foslevodopa/Foscarbidopa continuous subcutaneous infusion to arm, thigh, or flank versus abdomen in healthy and advanced Parkinson’s disease individuals

Bioequivalence of Foslevodopa/Foscarbidopa continuous subcutaneous infusion to arm, thigh, or flank versus abdomen in healthy and advanced Parkinson’s disease individuals

Background: Foslevodopa/foscarbidopa (LDp/CDp) are soluble prodrugs of levodopa/carbidopa delivered as a continuous subcutaneous infusion (CSCI) via a portable pump to provide continuous levodopa exposures. Objective: To assess the safety of LDp/CDp and the relative bioavailability of levodopa/carbi...

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Bibliographic Details
Main Authors: Yi Rang Han, Anna Jeong, Kanwal Ayub, Shelly V. Gupta, Lars Bergmann, Drew S. Kern, Fernando Pagan, Matthew Rosebraugh
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Clinical Parkinsonism & Related Disorders
Subjects:
Levodopa
Carbidopa
Advanced Parkinson’s disease
Subcutaneous infusions
Pharmacokinetics
Prodrugs
Online Access:http://www.sciencedirect.com/science/article/pii/S2590112525000635
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