Complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma: case report
The simultaneous occurrence of head and neck squamous carcinoma in two anatomical sites is rare, posing challenges in treatment selection. This paper presents a clinical case of concurrent hypopharyngeal carcinoma and nasopharyngeal carcinoma, successfully treated with a combination of chemoradiothe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1397877/full |
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| author | Xiameng Lu Xiameng Lu Bibo Tan Liuting Yang Suning Huang |
| author_facet | Xiameng Lu Xiameng Lu Bibo Tan Liuting Yang Suning Huang |
| author_sort | Xiameng Lu |
| collection | DOAJ |
| description | The simultaneous occurrence of head and neck squamous carcinoma in two anatomical sites is rare, posing challenges in treatment selection. This paper presents a clinical case of concurrent hypopharyngeal carcinoma and nasopharyngeal carcinoma, successfully treated with a combination of chemoradiotherapy and an immune checkpoint inhibitor. The patient achieved complete remission and progression-free survival of nearly 3 years, with preserved organ function and minimal toxic side effects, leading to a good quality of life. This case highlights the potential of combined concurrent chemoradiotherapy and immune checkpoint inhibitors in managing double primary HNSCC, offering a promising treatment option for these patients. |
| format | Article |
| id | doaj-art-604e46d1feb54806b6bac8ea7ab7ac92 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-604e46d1feb54806b6bac8ea7ab7ac922025-08-20T01:59:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-12-011410.3389/fonc.2024.13978771397877Complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma: case reportXiameng Lu0Xiameng Lu1Bibo Tan2Liuting Yang3Suning Huang4Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaMedical College of Oncology, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaDepartment of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaDepartment of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, ChinaThe simultaneous occurrence of head and neck squamous carcinoma in two anatomical sites is rare, posing challenges in treatment selection. This paper presents a clinical case of concurrent hypopharyngeal carcinoma and nasopharyngeal carcinoma, successfully treated with a combination of chemoradiotherapy and an immune checkpoint inhibitor. The patient achieved complete remission and progression-free survival of nearly 3 years, with preserved organ function and minimal toxic side effects, leading to a good quality of life. This case highlights the potential of combined concurrent chemoradiotherapy and immune checkpoint inhibitors in managing double primary HNSCC, offering a promising treatment option for these patients.https://www.frontiersin.org/articles/10.3389/fonc.2024.1397877/fullhead and neck carcinomadouble primary tumorimmune checkpoint inhibitorchemotherapyradiotherapycase report |
| spellingShingle | Xiameng Lu Xiameng Lu Bibo Tan Liuting Yang Suning Huang Complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma: case report Frontiers in Oncology head and neck carcinoma double primary tumor immune checkpoint inhibitor chemotherapy radiotherapy case report |
| title | Complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma: case report |
| title_full | Complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma: case report |
| title_fullStr | Complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma: case report |
| title_full_unstemmed | Complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma: case report |
| title_short | Complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma: case report |
| title_sort | complete remission after sintilimab combined with chemoradiotherapy in double primary head and neck carcinoma case report |
| topic | head and neck carcinoma double primary tumor immune checkpoint inhibitor chemotherapy radiotherapy case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1397877/full |
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