Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach
Abstract Cumulative risk assessment is significant for evaluating the combined exposure to multiple substances, but its widespread acceptance and application have been limited due to the complexity of clarifying and assessing actual exposure. In this study, we conducted a cumulative risk assessment...
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Nature Portfolio
2025-01-01
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| author | Jiahui Chen Jingrong Chen Mintao Li Ping Feng Mei Qin Ting Chen Shuquan Luo Jian Zhao Xiaofeng Yan Jinyao Chen Xuemei Lian Huadong Zhang Jiao Huo |
| author_facet | Jiahui Chen Jingrong Chen Mintao Li Ping Feng Mei Qin Ting Chen Shuquan Luo Jian Zhao Xiaofeng Yan Jinyao Chen Xuemei Lian Huadong Zhang Jiao Huo |
| author_sort | Jiahui Chen |
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| description | Abstract Cumulative risk assessment is significant for evaluating the combined exposure to multiple substances, but its widespread acceptance and application have been limited due to the complexity of clarifying and assessing actual exposure. In this study, we conducted a cumulative risk assessment based on hazard-driven criteria to evaluate the co-exposure to elemental contaminants in the diet of the population in Chongqing Municipality. The cumulative risk was calculated and evaluated using Monte Carlo modeling and the modified Reference Point Index (mRPI) method. Neurotoxicity and nephrotoxicity were identified as the main toxic endpoints, and the final evaluation elements included were Pb, Cd, As, and Hg. The results showed that the combined mRPI values for neurotoxicity and nephrotoxicity, resulting from exposure to the four heavy metals, ranged from 0.922 to 4.835 and 1.306 to 7.031, respectively. Cd and Pb were the primary contributors to nephrotoxicity, while Pb was the main contributor to neurotoxicity. The results indicated that combined dietary exposure to Pb, Cd, As, and Hg may pose risks of neurotoxicity and nephrotoxicity, with the combined exposure likely amplifying this risk compared to exposure to individual heavy metal elements. mRPI proves to be a more suitable index for cumulative risk assessment using a hazard-driven approach compared to other indexes, as it is derived based on specific studies and endpoints. |
| format | Article |
| id | doaj-art-604cc725532548978cb8011ffaa0da9f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-604cc725532548978cb8011ffaa0da9f2025-01-19T12:20:06ZengNature PortfolioScientific Reports2045-23222025-01-0115111810.1038/s41598-024-83299-2Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approachJiahui Chen0Jingrong Chen1Mintao Li2Ping Feng3Mei Qin4Ting Chen5Shuquan Luo6Jian Zhao7Xiaofeng Yan8Jinyao Chen9Xuemei Lian10Huadong Zhang11Jiao Huo12Chongqing Center for Disease Control and PreventionChongqing Center for Disease Control and PreventionChongqing Center for Disease Control and PreventionChongqing Center for Disease Control and PreventionChongqing Center for Disease Control and PreventionChongqing Center for Disease Control and PreventionChongqing Center for Disease Control and PreventionChongqing Center for Disease Control and PreventionChongqing Public Health Medical CenterDepartment of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan UniversitySchool of Public Health, Chongqing Medical UniversityChongqing Center for Disease Control and PreventionSchool of Public Health, Chongqing Medical UniversityAbstract Cumulative risk assessment is significant for evaluating the combined exposure to multiple substances, but its widespread acceptance and application have been limited due to the complexity of clarifying and assessing actual exposure. In this study, we conducted a cumulative risk assessment based on hazard-driven criteria to evaluate the co-exposure to elemental contaminants in the diet of the population in Chongqing Municipality. The cumulative risk was calculated and evaluated using Monte Carlo modeling and the modified Reference Point Index (mRPI) method. Neurotoxicity and nephrotoxicity were identified as the main toxic endpoints, and the final evaluation elements included were Pb, Cd, As, and Hg. The results showed that the combined mRPI values for neurotoxicity and nephrotoxicity, resulting from exposure to the four heavy metals, ranged from 0.922 to 4.835 and 1.306 to 7.031, respectively. Cd and Pb were the primary contributors to nephrotoxicity, while Pb was the main contributor to neurotoxicity. The results indicated that combined dietary exposure to Pb, Cd, As, and Hg may pose risks of neurotoxicity and nephrotoxicity, with the combined exposure likely amplifying this risk compared to exposure to individual heavy metal elements. mRPI proves to be a more suitable index for cumulative risk assessment using a hazard-driven approach compared to other indexes, as it is derived based on specific studies and endpoints.https://doi.org/10.1038/s41598-024-83299-2Dietary exposureHeavy metalsHazard-driven approachCumulative risk assessmentProbabilistic risk assessment |
| spellingShingle | Jiahui Chen Jingrong Chen Mintao Li Ping Feng Mei Qin Ting Chen Shuquan Luo Jian Zhao Xiaofeng Yan Jinyao Chen Xuemei Lian Huadong Zhang Jiao Huo Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach Scientific Reports Dietary exposure Heavy metals Hazard-driven approach Cumulative risk assessment Probabilistic risk assessment |
| title | Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach |
| title_full | Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach |
| title_fullStr | Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach |
| title_full_unstemmed | Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach |
| title_short | Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach |
| title_sort | probabilistic assessment of the cumulative risk from dietary heavy metal exposure in chongqing china using a hazard driven approach |
| topic | Dietary exposure Heavy metals Hazard-driven approach Cumulative risk assessment Probabilistic risk assessment |
| url | https://doi.org/10.1038/s41598-024-83299-2 |
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