Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi
The synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, w...
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| Format: | Article |
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The Journal of Infection in Developing Countries
2008-12-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/154 |
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| author | Javier Santander Kenneth L. Roland Roy Curtiss |
| author_facet | Javier Santander Kenneth L. Roland Roy Curtiss |
| author_sort | Javier Santander |
| collection | DOAJ |
| description | The synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, which masks clinical detection of LPS O-antigen. This variation in Vi polysaccharide and O-antigen display (VW variation) has been observed since the initial studies of S. Typhi. We have reported that the status of the rpoS gene is responsible for this phenomenon. We review the regulatory network of the Vi polysaccharide, linking osmolarity and RpoS expression. Also, we discuss how this may impact live attenuated Salmonella vaccine development. |
| format | Article |
| id | doaj-art-6048cceceae9461ab777ec67ecdc614f |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2008-12-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-6048cceceae9461ab777ec67ecdc614f2025-08-20T03:48:58ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802008-12-0120610.3855/jidc.154Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype TyphiJavier Santander0Kenneth L. Roland1Roy Curtiss2Center for Infectious Diseases and Vaccinology, The Biodesign Institute and School of Life Sciences, Arizona State UniversityCenter for Infectious Diseases and Vaccinology, The Biodesign Institute and School of Life Sciences, Arizona State UniversityCenter for Infectious Diseases and Vaccinology, The Biodesign Institute and School of Life Sciences, Arizona State UniversityThe synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, which masks clinical detection of LPS O-antigen. This variation in Vi polysaccharide and O-antigen display (VW variation) has been observed since the initial studies of S. Typhi. We have reported that the status of the rpoS gene is responsible for this phenomenon. We review the regulatory network of the Vi polysaccharide, linking osmolarity and RpoS expression. Also, we discuss how this may impact live attenuated Salmonella vaccine development.https://jidc.org/index.php/journal/article/view/154rpoSVW variationosmolarity |
| spellingShingle | Javier Santander Kenneth L. Roland Roy Curtiss Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi Journal of Infection in Developing Countries rpoS VW variation osmolarity |
| title | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
| title_full | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
| title_fullStr | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
| title_full_unstemmed | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
| title_short | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
| title_sort | regulation of vi capsular polysaccharide synthesis in salmonella enterica serotype typhi |
| topic | rpoS VW variation osmolarity |
| url | https://jidc.org/index.php/journal/article/view/154 |
| work_keys_str_mv | AT javiersantander regulationofvicapsularpolysaccharidesynthesisinsalmonellaentericaserotypetyphi AT kennethlroland regulationofvicapsularpolysaccharidesynthesisinsalmonellaentericaserotypetyphi AT roycurtiss regulationofvicapsularpolysaccharidesynthesisinsalmonellaentericaserotypetyphi |