Epigenetic dysregulation of H19/IGF2 in hepatic cells exposed to toxic metal mixtures in vitro

Epigenetic dysregulation of H19/IGF2 in hepatic cells exposed to toxic metal mixtures in vitro

Abstract Exposure to mixtures of toxic metals is known to cause adverse health effects through epigenetic alterations. Here we aimed to examine the unexplored area of aberrant DNA methylation in the H19/IGF2 domain following combined toxic metal exposure. An in vitro epigenotoxicity assay using the...

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Bibliographic Details
Main Authors: Yehoon Jo, Eugene Lim, Jihye Park, Keunsoo Kang, Mi-Yeon Shin, Jeong Weon Choi, Sungkyoon Kim, Jaehyouk Lee
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Toxic metals
Mixture exposure
Epigenotoxicity
H19/IGF2
DNA methylation
Online Access:https://doi.org/10.1038/s41598-024-80142-6
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