Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis
<b>Background/Objectives</b>: Prenatal adverse events may influence the development of complications of prematurity, including patent ductus arteriosus (PDA). We conducted a systematic review and Bayesian model-averaged (BMA) meta-analysis of observational studies exploring the associati...
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MDPI AG
2025-06-01
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| Series: | Children |
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| author | Moreyba Borges-Luján Gloria Galán-Henríquez Rosa I. Rodríguez-Viera František Bartoš Gema E. González-Luis Eduardo Villamor |
| author_facet | Moreyba Borges-Luján Gloria Galán-Henríquez Rosa I. Rodríguez-Viera František Bartoš Gema E. González-Luis Eduardo Villamor |
| author_sort | Moreyba Borges-Luján |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Prenatal adverse events may influence the development of complications of prematurity, including patent ductus arteriosus (PDA). We conducted a systematic review and Bayesian model-averaged (BMA) meta-analysis of observational studies exploring the association between hypertensive disorders of pregnancy (HDP) and the risk of PDA in preterm infants. <b>Methods</b>: PubMed/Medline and Embase databases were searched. We used BMA analysis to calculate Bayes factors (BFs). The BF<sub>10</sub> is the ratio of the probability of the data under the alternative hypothesis (H<sub>1</sub>, presence of association) over the probability of the data under the null hypothesis (H<sub>0</sub>, absence of association). <b>Results</b>: We included 41 studies (58,004 infants). BMA analysis showed moderate evidence in favour of H<sub>0</sub> for the association between HDP and any PDA (BF<sub>10</sub> = 0.20) as well as for the association between HDP and hemodynamically significant PDA (BF<sub>10</sub> = 0.27). Subgroup analyses based on the subtype of HDP showed that the moderate evidence in favour of H<sub>0</sub> was only conclusive (i.e., BF<sub>10</sub> < 0.33) for the associations of any PDA with preeclampsia (BF<sub>10</sub> = 0.30) and hemodynamically significant PDA with preeclampsia (BF<sub>10</sub> = 0.17). <b>Conclusions</b>: The currently available evidence suggests a lack of association between HDP and the risk of developing PDA. |
| format | Article |
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| institution | OA Journals |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-6044e3a971064b4b87876c8ad84e8b7f2025-08-20T02:24:34ZengMDPI AGChildren2227-90672025-06-0112676210.3390/children12060762Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-AnalysisMoreyba Borges-Luján0Gloria Galán-Henríquez1Rosa I. Rodríguez-Viera2František Bartoš3Gema E. González-Luis4Eduardo Villamor5Department of Pediatrics, Hospital Universitario Materno-Infantil de Canarias, 35016 Las Palmas de Gran Canaria, SpainDepartment of Pediatrics, Hospital Universitario Materno-Infantil de Canarias, 35016 Las Palmas de Gran Canaria, SpainDepartment of Pediatrics, Hospital Universitario Materno-Infantil de Canarias, 35016 Las Palmas de Gran Canaria, SpainDepartment of Psychology, University of Amsterdam, 1018WS Amsterdam, The NetherlandsDepartment of Pediatrics, Hospital Universitario Materno-Infantil de Canarias, 35016 Las Palmas de Gran Canaria, SpainDivision of Neonatology, MosaKids Children’s Hospital, Maastricht University Medical Center (MUMC+), Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6202AZ Maastricht, The Netherlands<b>Background/Objectives</b>: Prenatal adverse events may influence the development of complications of prematurity, including patent ductus arteriosus (PDA). We conducted a systematic review and Bayesian model-averaged (BMA) meta-analysis of observational studies exploring the association between hypertensive disorders of pregnancy (HDP) and the risk of PDA in preterm infants. <b>Methods</b>: PubMed/Medline and Embase databases were searched. We used BMA analysis to calculate Bayes factors (BFs). The BF<sub>10</sub> is the ratio of the probability of the data under the alternative hypothesis (H<sub>1</sub>, presence of association) over the probability of the data under the null hypothesis (H<sub>0</sub>, absence of association). <b>Results</b>: We included 41 studies (58,004 infants). BMA analysis showed moderate evidence in favour of H<sub>0</sub> for the association between HDP and any PDA (BF<sub>10</sub> = 0.20) as well as for the association between HDP and hemodynamically significant PDA (BF<sub>10</sub> = 0.27). Subgroup analyses based on the subtype of HDP showed that the moderate evidence in favour of H<sub>0</sub> was only conclusive (i.e., BF<sub>10</sub> < 0.33) for the associations of any PDA with preeclampsia (BF<sub>10</sub> = 0.30) and hemodynamically significant PDA with preeclampsia (BF<sub>10</sub> = 0.17). <b>Conclusions</b>: The currently available evidence suggests a lack of association between HDP and the risk of developing PDA.https://www.mdpi.com/2227-9067/12/6/762patent ductus arteriosuspreeclampsiapreterm infantBayesian statisticsmeta-analysis |
| spellingShingle | Moreyba Borges-Luján Gloria Galán-Henríquez Rosa I. Rodríguez-Viera František Bartoš Gema E. González-Luis Eduardo Villamor Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis Children patent ductus arteriosus preeclampsia preterm infant Bayesian statistics meta-analysis |
| title | Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis |
| title_full | Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis |
| title_fullStr | Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis |
| title_full_unstemmed | Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis |
| title_short | Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis |
| title_sort | association between hypertensive disorders of pregnancy and patent ductus arteriosus in very preterm infants a bayesian model averaged meta analysis |
| topic | patent ductus arteriosus preeclampsia preterm infant Bayesian statistics meta-analysis |
| url | https://www.mdpi.com/2227-9067/12/6/762 |
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