Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy

Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy

BackgroundCancer drug resistance significantly reduces the effectiveness of current anticancer treatments. Multiple dysregulated signaling pathways drive cancer initiation, progression, and related drug resistance. This highlights the need for developing new multi-targeting drugs that are more cost-...

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Bibliographic Details
Main Authors: Amin Aliabadi, Seyed Zachariah Moradi, Sadaf Abdian, Sajad Fakhri, Javier Echeverría
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
mebendazole
cancer drug resistance
drug repositioning
angiogenesis
apoptosis
signaling pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1631419/full
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