Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis
IntroductionThe dramatic hemodynamic disturbances induced by arteriovenous fistula (AVF) creation are universally acknowledged as the triggering factors for AVF dysfunction. The postoperative blood redistribution is greatly relevant with the flow disturbances of the AVF, such as disturbed flow, low...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1551993/full |
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| author | Yong-Jiang Li Yong-Jiang Li Hui-Min Hou Zheng Liu Chun-Dong Xue Chun-Dong Xue Jing-Tong Na Qing-Mei Meng Zhe-Yuan Li Hai-Yang Sun Yu-Lin Wu Shu-Xin Liu Shu-Xin Liu Kai-Rong Qin Kai-Rong Qin |
| author_facet | Yong-Jiang Li Yong-Jiang Li Hui-Min Hou Zheng Liu Chun-Dong Xue Chun-Dong Xue Jing-Tong Na Qing-Mei Meng Zhe-Yuan Li Hai-Yang Sun Yu-Lin Wu Shu-Xin Liu Shu-Xin Liu Kai-Rong Qin Kai-Rong Qin |
| author_sort | Yong-Jiang Li |
| collection | DOAJ |
| description | IntroductionThe dramatic hemodynamic disturbances induced by arteriovenous fistula (AVF) creation are universally acknowledged as the triggering factors for AVF dysfunction. The postoperative blood redistribution is greatly relevant with the flow disturbances of the AVF, such as disturbed flow, low wall shear stress (WSS), and oscillating WSS. However, the relationship between blood redistribution and hemodynamic disturbances of AVF remains unexamined. The role of clinically observed retrograde blood flow at the distal radial artery is rarely understood.MethodsIn this study, an idealized AVF model was developed with clinical data collected from end-stage renal disease patients. By considering the postoperative blood redistribution, the influence of the blood flow rate ratio on hemodynamic disturbances is numerically studied.Results and discussionThe results demonstrate that the creation of the AVF can result in flow disturbances such as vortex, reciprocating flow, and low and reciprocating WSS, whose occurrence regions are consistent with clinical observations. The flow rate ratio and flow direction of the distal radial artery play important roles in regulating the low-WSS area within the AVF anastomosis, especially for the flow rate of the proximal radial artery (PRA). Moreover, the clinically observed retrograde blood flow in the distal radial artery contributes to the reduction in the low-WSS area, revealing a compensatory mechanism. This study can provide valuable insights for understanding the effect of blood redistribution on flow disturbances in the AVF, as well as the compensatory role of the retrograde distal radial artery flow, which helps optimize blood redistribution for a well-functioning AVF. |
| format | Article |
| id | doaj-art-603d7ac3d3ac400baaa5d345b6ddcd9e |
| institution | DOAJ |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-603d7ac3d3ac400baaa5d345b6ddcd9e2025-08-20T02:50:45ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-03-011310.3389/fbioe.2025.15519931551993Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysisYong-Jiang Li0Yong-Jiang Li1Hui-Min Hou2Zheng Liu3Chun-Dong Xue4Chun-Dong Xue5Jing-Tong Na6Qing-Mei Meng7Zhe-Yuan Li8Hai-Yang Sun9Yu-Lin Wu10Shu-Xin Liu11Shu-Xin Liu12Kai-Rong Qin13Kai-Rong Qin14Institute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaSchool of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, ChinaSchool of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian, Liaoning, ChinaSchool of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian, Liaoning, ChinaInstitute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaSchool of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, ChinaInstitute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaInstitute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaInstitute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaInstitute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaInstitute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaInstitute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaSchool of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, ChinaInstitute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning, ChinaSchool of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, ChinaIntroductionThe dramatic hemodynamic disturbances induced by arteriovenous fistula (AVF) creation are universally acknowledged as the triggering factors for AVF dysfunction. The postoperative blood redistribution is greatly relevant with the flow disturbances of the AVF, such as disturbed flow, low wall shear stress (WSS), and oscillating WSS. However, the relationship between blood redistribution and hemodynamic disturbances of AVF remains unexamined. The role of clinically observed retrograde blood flow at the distal radial artery is rarely understood.MethodsIn this study, an idealized AVF model was developed with clinical data collected from end-stage renal disease patients. By considering the postoperative blood redistribution, the influence of the blood flow rate ratio on hemodynamic disturbances is numerically studied.Results and discussionThe results demonstrate that the creation of the AVF can result in flow disturbances such as vortex, reciprocating flow, and low and reciprocating WSS, whose occurrence regions are consistent with clinical observations. The flow rate ratio and flow direction of the distal radial artery play important roles in regulating the low-WSS area within the AVF anastomosis, especially for the flow rate of the proximal radial artery (PRA). Moreover, the clinically observed retrograde blood flow in the distal radial artery contributes to the reduction in the low-WSS area, revealing a compensatory mechanism. This study can provide valuable insights for understanding the effect of blood redistribution on flow disturbances in the AVF, as well as the compensatory role of the retrograde distal radial artery flow, which helps optimize blood redistribution for a well-functioning AVF.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1551993/fullarteriovenous fistulablood redistributioncomputational fluid dynamicsflow disturbancehemodialysis |
| spellingShingle | Yong-Jiang Li Yong-Jiang Li Hui-Min Hou Zheng Liu Chun-Dong Xue Chun-Dong Xue Jing-Tong Na Qing-Mei Meng Zhe-Yuan Li Hai-Yang Sun Yu-Lin Wu Shu-Xin Liu Shu-Xin Liu Kai-Rong Qin Kai-Rong Qin Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis Frontiers in Bioengineering and Biotechnology arteriovenous fistula blood redistribution computational fluid dynamics flow disturbance hemodialysis |
| title | Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis |
| title_full | Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis |
| title_fullStr | Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis |
| title_full_unstemmed | Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis |
| title_short | Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis |
| title_sort | adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula a computational fluid dynamics analysis |
| topic | arteriovenous fistula blood redistribution computational fluid dynamics flow disturbance hemodialysis |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1551993/full |
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