Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China
Tuberculosis (TB), particularly extremely drug-resistant TB (EDR-TB), remains a significant public health concern worldwide. Understanding the transmission patterns and epidemiological characteristics of EDR-TB is vital for effective disease control. Between 1 January 2006 and 31 December 2018, we c...
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Taylor & Francis Group
2025-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2025.2521842 |
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| author | Xiaoyu Lu Yuan Jiang Yanping Liu Junhong Chen Yinglin Lao Jing Li Yangyi Zhang Nan Li Lili Wang Chenlei Yu Qi Ye Wei Wei Jiale Deng Xin Shen Chongguang Yang |
| author_facet | Xiaoyu Lu Yuan Jiang Yanping Liu Junhong Chen Yinglin Lao Jing Li Yangyi Zhang Nan Li Lili Wang Chenlei Yu Qi Ye Wei Wei Jiale Deng Xin Shen Chongguang Yang |
| author_sort | Xiaoyu Lu |
| collection | DOAJ |
| description | Tuberculosis (TB), particularly extremely drug-resistant TB (EDR-TB), remains a significant public health concern worldwide. Understanding the transmission patterns and epidemiological characteristics of EDR-TB is vital for effective disease control. Between 1 January 2006 and 31 December 2018, we collected clinical M. tuberculosis strains in Shanghai, with whole-genome sequencing performed on 58 identified clinical EDR-TB strains. We analyzed EDR-related genetic mutations, conducted phylogenetic analyses, and examined bacterial and epidemiological factors that influence their transmission. Among these 58 EDR patients, 43.1% (25/58) were aged 45–64 years, with a median age of 51 years (interquartile range, IQR, 29–59 years). About two-thirds of the EDR-TB patients were residents. We observed a clustering rate of 44.8% (26/58) among EDR strains. Logistic regression analysis indicated a higher risk of recent EDR-TB transmission among the strains with the drug-resistant compensatory mutations. The primary mode of EDR-TB transmission in the study setting was recent, direct person-to-person spread of drug-resistant strains, as evidenced by high clustering rates and the presence of identical resistance mutations among clustered cases. |
| format | Article |
| id | doaj-art-603c0ebd998d477ebbc2fdc3bf08efee |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-603c0ebd998d477ebbc2fdc3bf08efee2025-08-20T02:44:49ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512025-12-0114110.1080/22221751.2025.2521842Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, ChinaXiaoyu Lu0Yuan Jiang1Yanping Liu2Junhong Chen3Yinglin Lao4Jing Li5Yangyi Zhang6Nan Li7Lili Wang8Chenlei Yu9Qi Ye10Wei Wei11Jiale Deng12Xin Shen13Chongguang Yang14School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaDivision of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of ChinaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaDivision of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of ChinaDivision of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of ChinaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaDivision of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of ChinaDivision of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of ChinaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaDivision of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of ChinaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s Republic of ChinaTuberculosis (TB), particularly extremely drug-resistant TB (EDR-TB), remains a significant public health concern worldwide. Understanding the transmission patterns and epidemiological characteristics of EDR-TB is vital for effective disease control. Between 1 January 2006 and 31 December 2018, we collected clinical M. tuberculosis strains in Shanghai, with whole-genome sequencing performed on 58 identified clinical EDR-TB strains. We analyzed EDR-related genetic mutations, conducted phylogenetic analyses, and examined bacterial and epidemiological factors that influence their transmission. Among these 58 EDR patients, 43.1% (25/58) were aged 45–64 years, with a median age of 51 years (interquartile range, IQR, 29–59 years). About two-thirds of the EDR-TB patients were residents. We observed a clustering rate of 44.8% (26/58) among EDR strains. Logistic regression analysis indicated a higher risk of recent EDR-TB transmission among the strains with the drug-resistant compensatory mutations. The primary mode of EDR-TB transmission in the study setting was recent, direct person-to-person spread of drug-resistant strains, as evidenced by high clustering rates and the presence of identical resistance mutations among clustered cases.https://www.tandfonline.com/doi/10.1080/22221751.2025.2521842EDR-TBtransmissionwhole-genome sequencingcompensatory mutationsChina |
| spellingShingle | Xiaoyu Lu Yuan Jiang Yanping Liu Junhong Chen Yinglin Lao Jing Li Yangyi Zhang Nan Li Lili Wang Chenlei Yu Qi Ye Wei Wei Jiale Deng Xin Shen Chongguang Yang Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China Emerging Microbes and Infections EDR-TB transmission whole-genome sequencing compensatory mutations China |
| title | Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China |
| title_full | Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China |
| title_fullStr | Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China |
| title_full_unstemmed | Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China |
| title_short | Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China |
| title_sort | genomic epidemiology analysis of extremely drug resistant tuberculosis in shanghai china |
| topic | EDR-TB transmission whole-genome sequencing compensatory mutations China |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2025.2521842 |
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