Comparison of stimulation sites enhancing dual-task performance using transcranial direct current stimulation in Parkinson’s disease
Abstract This pilot randomized crossover study aimed to compare the effects of stimulating various transcranial direct current stimulation (tDCS) target sites to improve dual-task performance in patients with Parkinson’s disease (PD). Nineteen patients with idiopathic PD completed four sessions of 2...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00869-5 |
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| author | Seo Jung Yun Sung Eun Hyun Woo Hyung Lee Byung-Mo Oh Han Gil Seo |
| author_facet | Seo Jung Yun Sung Eun Hyun Woo Hyung Lee Byung-Mo Oh Han Gil Seo |
| author_sort | Seo Jung Yun |
| collection | DOAJ |
| description | Abstract This pilot randomized crossover study aimed to compare the effects of stimulating various transcranial direct current stimulation (tDCS) target sites to improve dual-task performance in patients with Parkinson’s disease (PD). Nineteen patients with idiopathic PD completed four sessions of 2 mA anodal tDCS for 20 min at randomly assigned sites: the primary motor cortex (M1), left dorsolateral prefrontal cortex (DLPFC), ventromedial prefrontal cortex, and sham stimulation. Anodal M1 tDCS induced statistically significant improvements in single-task and cognitive dual-task timed up and go test. Additionally, enhancements were noted in the color-word Stroop test and trail-making test-Trail B following left DLPFC stimulation. However, none of the stimulation sites showed any significant changes in the dual-task effect. Overall, these results suggest that although tDCS targeting the M1 and DLPFC may immediately enhance motor and cognitive performances, respectively, neither has a significant effect on dual-task interference. |
| format | Article |
| id | doaj-art-6035aefd0c274adaa7d092f139992109 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-6035aefd0c274adaa7d092f1399921092025-01-19T12:14:37ZengNature Portfolionpj Parkinson's Disease2373-80572025-01-0111111010.1038/s41531-025-00869-5Comparison of stimulation sites enhancing dual-task performance using transcranial direct current stimulation in Parkinson’s diseaseSeo Jung Yun0Sung Eun Hyun1Woo Hyung Lee2Byung-Mo Oh3Han Gil Seo4Department of Rehabilitation Medicine, Seoul National University HospitalDepartment of Rehabilitation Medicine, Seoul National University HospitalDepartment of Rehabilitation Medicine, Seoul National University HospitalDepartment of Rehabilitation Medicine, Seoul National University HospitalDepartment of Rehabilitation Medicine, Seoul National University HospitalAbstract This pilot randomized crossover study aimed to compare the effects of stimulating various transcranial direct current stimulation (tDCS) target sites to improve dual-task performance in patients with Parkinson’s disease (PD). Nineteen patients with idiopathic PD completed four sessions of 2 mA anodal tDCS for 20 min at randomly assigned sites: the primary motor cortex (M1), left dorsolateral prefrontal cortex (DLPFC), ventromedial prefrontal cortex, and sham stimulation. Anodal M1 tDCS induced statistically significant improvements in single-task and cognitive dual-task timed up and go test. Additionally, enhancements were noted in the color-word Stroop test and trail-making test-Trail B following left DLPFC stimulation. However, none of the stimulation sites showed any significant changes in the dual-task effect. Overall, these results suggest that although tDCS targeting the M1 and DLPFC may immediately enhance motor and cognitive performances, respectively, neither has a significant effect on dual-task interference.https://doi.org/10.1038/s41531-025-00869-5 |
| spellingShingle | Seo Jung Yun Sung Eun Hyun Woo Hyung Lee Byung-Mo Oh Han Gil Seo Comparison of stimulation sites enhancing dual-task performance using transcranial direct current stimulation in Parkinson’s disease npj Parkinson's Disease |
| title | Comparison of stimulation sites enhancing dual-task performance using transcranial direct current stimulation in Parkinson’s disease |
| title_full | Comparison of stimulation sites enhancing dual-task performance using transcranial direct current stimulation in Parkinson’s disease |
| title_fullStr | Comparison of stimulation sites enhancing dual-task performance using transcranial direct current stimulation in Parkinson’s disease |
| title_full_unstemmed | Comparison of stimulation sites enhancing dual-task performance using transcranial direct current stimulation in Parkinson’s disease |
| title_short | Comparison of stimulation sites enhancing dual-task performance using transcranial direct current stimulation in Parkinson’s disease |
| title_sort | comparison of stimulation sites enhancing dual task performance using transcranial direct current stimulation in parkinson s disease |
| url | https://doi.org/10.1038/s41531-025-00869-5 |
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