Multicenter analysis for inter reader agreement of PIQUAL score v2 for basic readers in prostate MRI
Abstract The Prostate Imaging Quality (PI-QUAL) V2 is a simplified update of PI-QUAL V1 for assessing image quality in multiparametric prostate MRI (mpMRI), aimed at improving clinical use and reproducibility. This study evaluated inter-reader agreement of PI-QUAL V2 among basic prostate readers usi...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-02973-1 |
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| author | Mujgan Orman Sabri Sirolu Mustafa Ege Seker Deniz Alis Mustafa Said Kartal Yeliz Basar Nurper Denizoglu Serpil Kurtcan Aydan Arslan Ilkay Oksuz Ercan Karaarslan |
| author_facet | Mujgan Orman Sabri Sirolu Mustafa Ege Seker Deniz Alis Mustafa Said Kartal Yeliz Basar Nurper Denizoglu Serpil Kurtcan Aydan Arslan Ilkay Oksuz Ercan Karaarslan |
| author_sort | Mujgan Orman |
| collection | DOAJ |
| description | Abstract The Prostate Imaging Quality (PI-QUAL) V2 is a simplified update of PI-QUAL V1 for assessing image quality in multiparametric prostate MRI (mpMRI), aimed at improving clinical use and reproducibility. This study evaluated inter-reader agreement of PI-QUAL V2 among basic prostate readers using multicenter mpMRI data and compared it to PI-QUAL V1. Five readers assessed T2-weighted, DWI (including ADC maps), and DCE images from 274 men (median age: 71 years, IQR: 60–78) across five centers. Inter-reader agreement was measured using weighted Gwet’s AC1 coefficients and compared using bootstrapped confidence intervals. For PI-QUAL V1, coefficients ranged from 0.659 to 0.855, indicating substantial-to-almost perfect agreement. For PI-QUAL V2, coefficients ranged from 0.821 to 0.897, showing almost perfect agreement. All 10 pairwise comparisons achieved almost perfect agreement for PI-QUAL V2, compared to only 3 of 10 for V1. Additionally, three comparisons showed non-overlapping confidence intervals, indicating statistically significant improvements with V2. PI-QUAL V2 demonstrated consistently higher inter-reader agreement than V1, with basic prostate readers achieving almost perfect agreement across multicenter mpMRI data. These findings highlight the improved reliability and clinical applicability of PI-QUAL V2. |
| format | Article |
| id | doaj-art-60329fc42447414cabefe2b569199ff5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-60329fc42447414cabefe2b569199ff52025-08-20T03:45:23ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-02973-1Multicenter analysis for inter reader agreement of PIQUAL score v2 for basic readers in prostate MRIMujgan Orman0Sabri Sirolu1Mustafa Ege Seker2Deniz Alis3Mustafa Said Kartal4Yeliz Basar5Nurper Denizoglu6Serpil Kurtcan7Aydan Arslan8Ilkay Oksuz9Ercan Karaarslan10Department of Radiology, Acibadem Healthcare GroupDepartment of Radiology, Istanbul Sisli Hamidiye Etfal Training and Research HospitalSchool of Medicine, Department of Radiology, University of Wisconsin-MadisonSchool of Medicine, Department of Radiology, Acibadem Mehmet Ali Aydinlar UniversitySchool of Medicine, Cumhuriyet UniversityDepartment of Radiology, Acibadem Healthcare GroupDepartment of Radiology, Sultan 2. Abdulhamid Han Training and Research HospitalDepartment of Radiology, Acibadem Healthcare GroupDepartment of Radiology, Umraniye Training and Research HospitalDepartment of Computer Engineering, Istanbul Technical UniversitySchool of Medicine, Department of Radiology, Acibadem Mehmet Ali Aydinlar UniversityAbstract The Prostate Imaging Quality (PI-QUAL) V2 is a simplified update of PI-QUAL V1 for assessing image quality in multiparametric prostate MRI (mpMRI), aimed at improving clinical use and reproducibility. This study evaluated inter-reader agreement of PI-QUAL V2 among basic prostate readers using multicenter mpMRI data and compared it to PI-QUAL V1. Five readers assessed T2-weighted, DWI (including ADC maps), and DCE images from 274 men (median age: 71 years, IQR: 60–78) across five centers. Inter-reader agreement was measured using weighted Gwet’s AC1 coefficients and compared using bootstrapped confidence intervals. For PI-QUAL V1, coefficients ranged from 0.659 to 0.855, indicating substantial-to-almost perfect agreement. For PI-QUAL V2, coefficients ranged from 0.821 to 0.897, showing almost perfect agreement. All 10 pairwise comparisons achieved almost perfect agreement for PI-QUAL V2, compared to only 3 of 10 for V1. Additionally, three comparisons showed non-overlapping confidence intervals, indicating statistically significant improvements with V2. PI-QUAL V2 demonstrated consistently higher inter-reader agreement than V1, with basic prostate readers achieving almost perfect agreement across multicenter mpMRI data. These findings highlight the improved reliability and clinical applicability of PI-QUAL V2.https://doi.org/10.1038/s41598-025-02973-1ProstateMRIProstate CancerPI-QUALImage quality |
| spellingShingle | Mujgan Orman Sabri Sirolu Mustafa Ege Seker Deniz Alis Mustafa Said Kartal Yeliz Basar Nurper Denizoglu Serpil Kurtcan Aydan Arslan Ilkay Oksuz Ercan Karaarslan Multicenter analysis for inter reader agreement of PIQUAL score v2 for basic readers in prostate MRI Scientific Reports Prostate MRI Prostate Cancer PI-QUAL Image quality |
| title | Multicenter analysis for inter reader agreement of PIQUAL score v2 for basic readers in prostate MRI |
| title_full | Multicenter analysis for inter reader agreement of PIQUAL score v2 for basic readers in prostate MRI |
| title_fullStr | Multicenter analysis for inter reader agreement of PIQUAL score v2 for basic readers in prostate MRI |
| title_full_unstemmed | Multicenter analysis for inter reader agreement of PIQUAL score v2 for basic readers in prostate MRI |
| title_short | Multicenter analysis for inter reader agreement of PIQUAL score v2 for basic readers in prostate MRI |
| title_sort | multicenter analysis for inter reader agreement of piqual score v2 for basic readers in prostate mri |
| topic | Prostate MRI Prostate Cancer PI-QUAL Image quality |
| url | https://doi.org/10.1038/s41598-025-02973-1 |
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