Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old Boy
Ewing’s Sarcoma (ES) is a highly malignant bone tumour. It may involve any part of the skeleton but the most frequent parts are the ilium and diaphysis of femur and tibia (Alfeeli et al., 2005; Zhu et al., 2012). Primary ES of the spine is extremely rare (Yan et al., 2011). It accounts for only 3.5...
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Wiley
2016-01-01
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| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2016/8027137 |
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| author | Ali J. Electricwala Jaffer T. Electricwala |
| author_facet | Ali J. Electricwala Jaffer T. Electricwala |
| author_sort | Ali J. Electricwala |
| collection | DOAJ |
| description | Ewing’s Sarcoma (ES) is a highly malignant bone tumour. It may involve any part of the skeleton but the most frequent parts are the ilium and diaphysis of femur and tibia (Alfeeli et al., 2005; Zhu et al., 2012). Primary ES of the spine is extremely rare (Yan et al., 2011). It accounts for only 3.5 to 14.9 percent of all primary bone sarcomas. The age of presentation ranges from 12 to 24 years (median 21 years) (Ferguson, 1999; Sharafuddin et al., 1992; Klimo Jr. et al., 2009). We report an unusual case of primary ES of the spine in a two-year-old boy, who presented to us with paraparesis and features of cauda equina syndrome. MRI scan showed a tumour mass arising from the pedicle of L4 vertebra invading the spinal canal. Tc-99 bone scan showed increased tracer uptake in L4 vertebra and normal tracer uptake elsewhere in the skeleton. After reaching the diagnosis of a space occupying lesion invading the lumber spinal canal, we performed a decompressive laminectomy and a biopsy was sent which confirmed the diagnosis of ES. Immunohistochemistry showed tumour cells staining positive for CD-99 (specific stain for ES). Gene testing showed an EWS-FLI 1 chimera. Surgery was followed by good improvement in motor signs. The child was then referred to a specialized oncotherapy centre for further treatment, radiation, and chemotherapy. To the best of our knowledge, we are the first to report primary ES of the spine at the age of two years. |
| format | Article |
| id | doaj-art-602f0b1da3da42e98e5a0f98d3990907 |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Case Reports in Orthopedics |
| spelling | doaj-art-602f0b1da3da42e98e5a0f98d39909072025-02-03T06:48:07ZengWileyCase Reports in Orthopedics2090-67492090-67572016-01-01201610.1155/2016/80271378027137Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old BoyAli J. Electricwala0Jaffer T. Electricwala1Electricwala Hospital and Clinics, Himalayan Heights, Pune, Maharashtra 411013, IndiaElectricwala Hospital and Clinics, Himalayan Heights, Pune, Maharashtra 411013, IndiaEwing’s Sarcoma (ES) is a highly malignant bone tumour. It may involve any part of the skeleton but the most frequent parts are the ilium and diaphysis of femur and tibia (Alfeeli et al., 2005; Zhu et al., 2012). Primary ES of the spine is extremely rare (Yan et al., 2011). It accounts for only 3.5 to 14.9 percent of all primary bone sarcomas. The age of presentation ranges from 12 to 24 years (median 21 years) (Ferguson, 1999; Sharafuddin et al., 1992; Klimo Jr. et al., 2009). We report an unusual case of primary ES of the spine in a two-year-old boy, who presented to us with paraparesis and features of cauda equina syndrome. MRI scan showed a tumour mass arising from the pedicle of L4 vertebra invading the spinal canal. Tc-99 bone scan showed increased tracer uptake in L4 vertebra and normal tracer uptake elsewhere in the skeleton. After reaching the diagnosis of a space occupying lesion invading the lumber spinal canal, we performed a decompressive laminectomy and a biopsy was sent which confirmed the diagnosis of ES. Immunohistochemistry showed tumour cells staining positive for CD-99 (specific stain for ES). Gene testing showed an EWS-FLI 1 chimera. Surgery was followed by good improvement in motor signs. The child was then referred to a specialized oncotherapy centre for further treatment, radiation, and chemotherapy. To the best of our knowledge, we are the first to report primary ES of the spine at the age of two years.http://dx.doi.org/10.1155/2016/8027137 |
| spellingShingle | Ali J. Electricwala Jaffer T. Electricwala Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old Boy Case Reports in Orthopedics |
| title | Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old Boy |
| title_full | Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old Boy |
| title_fullStr | Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old Boy |
| title_full_unstemmed | Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old Boy |
| title_short | Primary Ewing’s Sarcoma of the Spine in a Two-Year-Old Boy |
| title_sort | primary ewing s sarcoma of the spine in a two year old boy |
| url | http://dx.doi.org/10.1155/2016/8027137 |
| work_keys_str_mv | AT alijelectricwala primaryewingssarcomaofthespineinatwoyearoldboy AT jaffertelectricwala primaryewingssarcomaofthespineinatwoyearoldboy |