Cholesterol confers resistance to Apatinib-mediated ferroptosis in gastric cancer

Cholesterol confers resistance to Apatinib-mediated ferroptosis in gastric cancer

Abstract Background Gastric cancer is the fifth leading cause of cancer-related deaths worldwide. Apatinib is a third-line treatment for gastric cancer. However, the development of resistance significantly limits its efficacy, and effective and safe strategies to overcome Apatinib resistance remain...

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Bibliographic Details
Main Authors: Zhiwei Li, Chenxin Liu, Minghao Wang, Riqing Wei, Ru Li, Kaihua Huang, Huayuan Liang, Guoxin Li, Liying Zhao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell & Bioscience
Subjects:
Gastric cancer
Apatinib
Ferroptosis
Cholesterol
HMGCR
Online Access:https://doi.org/10.1186/s13578-025-01435-5
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