HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth
HIC-5 is a multidomain LIM protein homologous to paxillin that serves as a molecular scaffold at focal adhesions and in the nucleus. It forms mobile molecular units with LIM-only proteins, PINCH, and CRP2 and translocates in and out of the nucleus via a nuclear export signal (NES). Of note, NES of H...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/426138 |
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| author | Motoko Shibanuma Kazunori Mori Kiyoshi Nose |
| author_facet | Motoko Shibanuma Kazunori Mori Kiyoshi Nose |
| author_sort | Motoko Shibanuma |
| collection | DOAJ |
| description | HIC-5 is a multidomain LIM protein homologous to paxillin that serves as a molecular scaffold at focal adhesions and in the nucleus. It forms mobile molecular units with LIM-only proteins, PINCH, and CRP2 and translocates in and out of the nucleus via a nuclear export signal (NES). Of note, NES of HIC-5 is distinctive in its sensitivity to the cellular redox state. Recently, the mobile units of HIC-5 have been suggested to be involved in the regulation of the anchorage dependence of cell growth. On loss of adhesion, an increase in reactive oxygen species in the cells modifies NES and stops shuttling, which leads to cell-cycle control. More specifically, the system circumvents nuclear localization of cyclin D1 and transactivates p21Cip1 in detached cells, thereby avoiding anchorage-independent cell growth. Thus, the HIC-5-LIM only protein complex has emerged as a fail-safe system for regulating the anchorage dependence of cell growth. |
| format | Article |
| id | doaj-art-6023ca48c1164cb097d033a3bffa8c19 |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-6023ca48c1164cb097d033a3bffa8c192025-08-20T02:35:21ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/426138426138HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell GrowthMotoko Shibanuma0Kazunori Mori1Kiyoshi Nose2Department of Cancer Cell Biology, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Cancer Cell Biology, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Cancer Cell Biology, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanHIC-5 is a multidomain LIM protein homologous to paxillin that serves as a molecular scaffold at focal adhesions and in the nucleus. It forms mobile molecular units with LIM-only proteins, PINCH, and CRP2 and translocates in and out of the nucleus via a nuclear export signal (NES). Of note, NES of HIC-5 is distinctive in its sensitivity to the cellular redox state. Recently, the mobile units of HIC-5 have been suggested to be involved in the regulation of the anchorage dependence of cell growth. On loss of adhesion, an increase in reactive oxygen species in the cells modifies NES and stops shuttling, which leads to cell-cycle control. More specifically, the system circumvents nuclear localization of cyclin D1 and transactivates p21Cip1 in detached cells, thereby avoiding anchorage-independent cell growth. Thus, the HIC-5-LIM only protein complex has emerged as a fail-safe system for regulating the anchorage dependence of cell growth.http://dx.doi.org/10.1155/2012/426138 |
| spellingShingle | Motoko Shibanuma Kazunori Mori Kiyoshi Nose HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth International Journal of Cell Biology |
| title | HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth |
| title_full | HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth |
| title_fullStr | HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth |
| title_full_unstemmed | HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth |
| title_short | HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth |
| title_sort | hic 5 a mobile molecular scaffold regulating the anchorage dependence of cell growth |
| url | http://dx.doi.org/10.1155/2012/426138 |
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