Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence
Integrating evidence from animal experiments is a critical component of biomedical research, providing essential prior information for in-depth investigations of disease mechanisms and new drug development. Animal models have played an irreplaceable role in simulating human diseases. However, the in...
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| Format: | Article |
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Editorial Office of Laboratory Animal and Comparative Medicine
2024-10-01
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| Series: | Shiyan dongwu yu bijiao yixue |
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| Online Access: | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.079 |
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| author | ZHENG Qingyong LI Tengfei XU Jianguo ZHOU Yongjia MA Zhichao WANG Na LI Molan YANG Wenjing WU Peirun WANG Haidong TIAN Jinhui |
| author_facet | ZHENG Qingyong LI Tengfei XU Jianguo ZHOU Yongjia MA Zhichao WANG Na LI Molan YANG Wenjing WU Peirun WANG Haidong TIAN Jinhui |
| author_sort | ZHENG Qingyong |
| collection | DOAJ |
| description | Integrating evidence from animal experiments is a critical component of biomedical research, providing essential prior information for in-depth investigations of disease mechanisms and new drug development. Animal models have played an irreplaceable role in simulating human diseases. However, the integration of evidence from animal experiments has faced numerous challenges, including insufficient emphasis, significant heterogeneity in study designs, high publication bias, and discrepancies with clinical research practices. This paper first identifies existing issues in the original research evidence from animal experiments, such as the selection and applicability of animal models, considerations in the design of experimental studies, and factors influencing the translation of animal experimental evidence. It then discusses various methods for integrating this evidence, including systematic review and meta-analysis, overview of systematic review/umbrella review, scoping review, and evidence mapping, while highlighting recent advancements in their application. Finally, the paper addresses the main challenges currently encountered in the integration of evidence from animal experiments and proposes targeted improvement strategies aimed at enhancing the efficiency of translating research outcomes into clinical practice and promoting the advancement of evidence-based medicine. By continuously optimizing original experimental research protocols and evidence integration practices, this work aims to establish a more efficient and scientific environment for the synthesis of evidence from animal experiments, ultimately contributing to clinical trials and human health. |
| format | Article |
| id | doaj-art-602285ad98814db2a482d64258fe0138 |
| institution | Kabale University |
| issn | 1674-5817 |
| language | zho |
| publishDate | 2024-10-01 |
| publisher | Editorial Office of Laboratory Animal and Comparative Medicine |
| record_format | Article |
| series | Shiyan dongwu yu bijiao yixue |
| spelling | doaj-art-602285ad98814db2a482d64258fe01382025-01-06T05:07:29ZzhoEditorial Office of Laboratory Animal and Comparative MedicineShiyan dongwu yu bijiao yixue1674-58172024-10-0144556757610.12300/j.issn.1674-5817.2024.0791674-5817（2024）05-0567-10Advances and Challenges in the Research of Integration Methods of Animal Experimental EvidenceZHENG Qingyong0LI Tengfei1XU Jianguo2ZHOU Yongjia3MA Zhichao4WANG Na5LI Molan6YANG Wenjing7WU Peirun8WANG Haidong9TIAN Jinhui10Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou730000, ChinaSchool of Nursing, Gansu University of Chinese Medicine, Lanzhou730000, ChinaEvidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou730000, ChinaSchool of Nursing, Gansu University of Chinese Medicine, Lanzhou730000, ChinaThe Second Clinical Medical College of Lanzhou University, Lanzhou730000, ChinaThe First Clinical School of Medicine, Lanzhou University, Lanzhou730000, ChinaThe First Clinical School of Medicine, Lanzhou University, Lanzhou730000, ChinaThe First Clinical School of Medicine, Lanzhou University, Lanzhou730000, ChinaThe Second Clinical Medical College of Lanzhou University, Lanzhou730000, ChinaGansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou730050, ChinaEvidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou730000, ChinaIntegrating evidence from animal experiments is a critical component of biomedical research, providing essential prior information for in-depth investigations of disease mechanisms and new drug development. Animal models have played an irreplaceable role in simulating human diseases. However, the integration of evidence from animal experiments has faced numerous challenges, including insufficient emphasis, significant heterogeneity in study designs, high publication bias, and discrepancies with clinical research practices. This paper first identifies existing issues in the original research evidence from animal experiments, such as the selection and applicability of animal models, considerations in the design of experimental studies, and factors influencing the translation of animal experimental evidence. It then discusses various methods for integrating this evidence, including systematic review and meta-analysis, overview of systematic review/umbrella review, scoping review, and evidence mapping, while highlighting recent advancements in their application. Finally, the paper addresses the main challenges currently encountered in the integration of evidence from animal experiments and proposes targeted improvement strategies aimed at enhancing the efficiency of translating research outcomes into clinical practice and promoting the advancement of evidence-based medicine. By continuously optimizing original experimental research protocols and evidence integration practices, this work aims to establish a more efficient and scientific environment for the synthesis of evidence from animal experiments, ultimately contributing to clinical trials and human health.https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.079animal experimentsevidence integrationresearch progressevidence-based medicine |
| spellingShingle | ZHENG Qingyong LI Tengfei XU Jianguo ZHOU Yongjia MA Zhichao WANG Na LI Molan YANG Wenjing WU Peirun WANG Haidong TIAN Jinhui Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence Shiyan dongwu yu bijiao yixue animal experiments evidence integration research progress evidence-based medicine |
| title | Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence |
| title_full | Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence |
| title_fullStr | Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence |
| title_full_unstemmed | Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence |
| title_short | Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence |
| title_sort | advances and challenges in the research of integration methods of animal experimental evidence |
| topic | animal experiments evidence integration research progress evidence-based medicine |
| url | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.079 |
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