The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trial
Abstract INTRODUCTION Alzheimer's disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Participation in moderate‐to‐vigorous physical activity (MVPA) may prevent or delay the onset of AD. Therefore, we evaluated the potential effectiveness of a remotely delivered h...
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Wiley
2025-04-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1002/trc2.70115 |
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| author | Lauren T. Ptomey Brian C. Helsel Richard A. Washburn Robert N. Montgomery Ron Krebill Jessica C. Danon Joseph R. Sherman Daniel Forsha Amy Bodde Amanda N. Szabo‐Reed Anna M. Gorczyca Joseph E. Donnelly |
| author_facet | Lauren T. Ptomey Brian C. Helsel Richard A. Washburn Robert N. Montgomery Ron Krebill Jessica C. Danon Joseph R. Sherman Daniel Forsha Amy Bodde Amanda N. Szabo‐Reed Anna M. Gorczyca Joseph E. Donnelly |
| author_sort | Lauren T. Ptomey |
| collection | DOAJ |
| description | Abstract INTRODUCTION Alzheimer's disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Participation in moderate‐to‐vigorous physical activity (MVPA) may prevent or delay the onset of AD. Therefore, we evaluated the potential effectiveness of a remotely delivered home‐based group exercise (≈8/group) to increase daily MVPA and cardiorespiratory fitness in adults with DS to a level that may be associated with delaying AD in adults with DS. METHODS Adults with DS (n = 81, age ≈27 years 55% female) without dementia were randomized (2:2:1) to a 12‐month intervention, which included 40‐min exercise sessions scheduled once (remote low (RL), n = 32) or 3 times per week (remote high (RH), n = 34) plus twice monthly 20‐min individual remotely delivered support/education sessions or to a control arm who attended twice monthly support/education sessions only (SE, n = 15). MVPA (minutes/day) was assessed by accelerometer, and cardiorespiratory fitness (VO2 Peak, mL/kg/min) was assessed using a maximal treadmill test RESULTS Participant retention at 12 months was 100%. Attendance at exercise and support/education sessions averaged ~85% and ~86%, respectively. Linear mixed modeling revealed no significant differences in change in MVPA from baseline to 12 months between the RH (10 min/day) and the RL arms (2 min/day, p = 0.06) or the RH and SE arms (1 min/day p = 0.13). The change in VO₂ Peak differed significantly between the RH (2.0 ± 4.6 mL/kg/min) and RL arms (−1.1 ± 3.0 mL/kg/min, p = 0.04) but not between the RH and SE arms (1.2 ± 5.3 mL/kg/min, p = 0.85). DISCUSSION Our results suggest that remotely delivered group exercise (3 times/week) in conjunction with twice‐monthly support/education is feasible and may increase daily MVPA and cardiorespiratory fitness to a level that may be associated with improvements in health and cognitive parameters in adults with DS. CLINICAL TRIALS REGISTRATION This trial was approved by the Institutional Review Board at the University of Kansas Medical Center and was registered on clinicaltrials.gov (NCT04048759). Highlights Evidence suggests that exercise may delay Alzheimer's disease (AD) in the general population, but its impact on adults with Down syndrome (DS) remains unknown. Adults attended remote exercise sessions either 1 or 3 times a week or received basic education about exercise. Those who attend exercise sessions 3 times a week increased their physical activity by 70 min per week. Those who attend exercise sessions 3 times a week improve their cardiorespiratory fitness. Remote exercise can be used in future AD prevention trials in adults with DS. |
| format | Article |
| id | doaj-art-6017e7326d094566951d8acf74fb127c |
| institution | OA Journals |
| issn | 2352-8737 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
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| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-6017e7326d094566951d8acf74fb127c2025-08-20T02:22:09ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372025-04-01112n/an/a10.1002/trc2.70115The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trialLauren T. Ptomey0Brian C. Helsel1Richard A. Washburn2Robert N. Montgomery3Ron Krebill4Jessica C. Danon5Joseph R. Sherman6Daniel Forsha7Amy Bodde8Amanda N. Szabo‐Reed9Anna M. Gorczyca10Joseph E. Donnelly11Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USADepartment of Neurology University of Kansas Medical Center Kansas City Kansas USADepartment of Internal Medicine University of Kansas Medical Center Kansas City Kansas USADepartment of Biostatistics & Data Science University of Kansas Medical Center Kansas City Kansas USADepartment of Biostatistics & Data Science University of Kansas Medical Center Kansas City Kansas USADepartment of Internal Medicine University of Kansas Medical Center Kansas City Kansas USADepartment of Internal Medicine University of Kansas Medical Center Kansas City Kansas USAWard Family Heart Center Children's Mercy Kansas City Kansas City Missouri USADepartment of Internal Medicine University of Kansas Medical Center Kansas City Kansas USADepartment of Internal Medicine University of Kansas Medical Center Kansas City Kansas USADepartment of Internal Medicine University of Kansas Medical Center Kansas City Kansas USADepartment of Internal Medicine University of Kansas Medical Center Kansas City Kansas USAAbstract INTRODUCTION Alzheimer's disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Participation in moderate‐to‐vigorous physical activity (MVPA) may prevent or delay the onset of AD. Therefore, we evaluated the potential effectiveness of a remotely delivered home‐based group exercise (≈8/group) to increase daily MVPA and cardiorespiratory fitness in adults with DS to a level that may be associated with delaying AD in adults with DS. METHODS Adults with DS (n = 81, age ≈27 years 55% female) without dementia were randomized (2:2:1) to a 12‐month intervention, which included 40‐min exercise sessions scheduled once (remote low (RL), n = 32) or 3 times per week (remote high (RH), n = 34) plus twice monthly 20‐min individual remotely delivered support/education sessions or to a control arm who attended twice monthly support/education sessions only (SE, n = 15). MVPA (minutes/day) was assessed by accelerometer, and cardiorespiratory fitness (VO2 Peak, mL/kg/min) was assessed using a maximal treadmill test RESULTS Participant retention at 12 months was 100%. Attendance at exercise and support/education sessions averaged ~85% and ~86%, respectively. Linear mixed modeling revealed no significant differences in change in MVPA from baseline to 12 months between the RH (10 min/day) and the RL arms (2 min/day, p = 0.06) or the RH and SE arms (1 min/day p = 0.13). The change in VO₂ Peak differed significantly between the RH (2.0 ± 4.6 mL/kg/min) and RL arms (−1.1 ± 3.0 mL/kg/min, p = 0.04) but not between the RH and SE arms (1.2 ± 5.3 mL/kg/min, p = 0.85). DISCUSSION Our results suggest that remotely delivered group exercise (3 times/week) in conjunction with twice‐monthly support/education is feasible and may increase daily MVPA and cardiorespiratory fitness to a level that may be associated with improvements in health and cognitive parameters in adults with DS. CLINICAL TRIALS REGISTRATION This trial was approved by the Institutional Review Board at the University of Kansas Medical Center and was registered on clinicaltrials.gov (NCT04048759). Highlights Evidence suggests that exercise may delay Alzheimer's disease (AD) in the general population, but its impact on adults with Down syndrome (DS) remains unknown. Adults attended remote exercise sessions either 1 or 3 times a week or received basic education about exercise. Those who attend exercise sessions 3 times a week increased their physical activity by 70 min per week. Those who attend exercise sessions 3 times a week improve their cardiorespiratory fitness. Remote exercise can be used in future AD prevention trials in adults with DS.https://doi.org/10.1002/trc2.70115Alzheimer'sdementiaDown syndromeexercisefitnessintervention |
| spellingShingle | Lauren T. Ptomey Brian C. Helsel Richard A. Washburn Robert N. Montgomery Ron Krebill Jessica C. Danon Joseph R. Sherman Daniel Forsha Amy Bodde Amanda N. Szabo‐Reed Anna M. Gorczyca Joseph E. Donnelly The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trial Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's dementia Down syndrome exercise fitness intervention |
| title | The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trial |
| title_full | The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trial |
| title_fullStr | The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trial |
| title_full_unstemmed | The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trial |
| title_short | The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trial |
| title_sort | promotion of physical activity for use in alzheimer s disease prevention trials in adults with down syndrome results from a 12 month randomized trial |
| topic | Alzheimer's dementia Down syndrome exercise fitness intervention |
| url | https://doi.org/10.1002/trc2.70115 |
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