The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking
Background: Helicobacter pylori is a Gram negative bacterium in the human stomach. Considering the side effects of the drug regimen and the prevalence of antibiotic resistance, in this project, the antimicrobial effect of aloe vera extracts on Helicobacter pylori was tested. Materials and Methods: E...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-02-01
|
| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/abr.abr_141_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850038759883538432 |
|---|---|
| author | Roghayeh Farajnabi Zahra Hojjati Bonab Neda Shagayegh |
| author_facet | Roghayeh Farajnabi Zahra Hojjati Bonab Neda Shagayegh |
| author_sort | Roghayeh Farajnabi |
| collection | DOAJ |
| description | Background:
Helicobacter pylori is a Gram negative bacterium in the human stomach. Considering the side effects of the drug regimen and the prevalence of antibiotic resistance, in this project, the antimicrobial effect of aloe vera extracts on Helicobacter pylori was tested.
Materials and Methods:
Evaluation of the antimicrobial effect of aloe vera extract on Helicobacter pylori was done using diffusion methods in agar, and the diameter of the nongrowth halo was measured. The molecular interaction between the active ingredients of aloe vera and urease enzyme was investigated with Mulgroo Virtual Docker (MVD) software.
Results:
The diameter of the halo of no growth at a concentration of 1000 mg/ml in aloe vera was 19 mm, and the maximum diameter of no growth was observed in the ethanolic extract.
Conclusion:
According to our results, the ethanolic extract of aloe vera can be suggested as a good option as an antimicrobial supplement for Helicobacter pylori. |
| format | Article |
| id | doaj-art-600d933d53864ff787ec2a3405314d5e |
| institution | DOAJ |
| issn | 2277-9175 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj-art-600d933d53864ff787ec2a3405314d5e2025-08-20T02:56:30ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752025-02-01141101010.4103/abr.abr_141_24The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular DockingRoghayeh FarajnabiZahra Hojjati BonabNeda ShagayeghBackground: Helicobacter pylori is a Gram negative bacterium in the human stomach. Considering the side effects of the drug regimen and the prevalence of antibiotic resistance, in this project, the antimicrobial effect of aloe vera extracts on Helicobacter pylori was tested. Materials and Methods: Evaluation of the antimicrobial effect of aloe vera extract on Helicobacter pylori was done using diffusion methods in agar, and the diameter of the nongrowth halo was measured. The molecular interaction between the active ingredients of aloe vera and urease enzyme was investigated with Mulgroo Virtual Docker (MVD) software. Results: The diameter of the halo of no growth at a concentration of 1000 mg/ml in aloe vera was 19 mm, and the maximum diameter of no growth was observed in the ethanolic extract. Conclusion: According to our results, the ethanolic extract of aloe vera can be suggested as a good option as an antimicrobial supplement for Helicobacter pylori.https://journals.lww.com/10.4103/abr.abr_141_24aloe vera extractantimicrobialhelicobacter pylorimolecular docking |
| spellingShingle | Roghayeh Farajnabi Zahra Hojjati Bonab Neda Shagayegh The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking Advanced Biomedical Research aloe vera extract antimicrobial helicobacter pylori molecular docking |
| title | The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking |
| title_full | The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking |
| title_fullStr | The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking |
| title_full_unstemmed | The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking |
| title_short | The in Vitro Antimicrobial Effect of Ethanolic Extracts of Aloe Vera on the H-pylori and Inhibitory Effect of Secondary Metabolites of Aloe Vera by Molecular Docking |
| title_sort | in vitro antimicrobial effect of ethanolic extracts of aloe vera on the h pylori and inhibitory effect of secondary metabolites of aloe vera by molecular docking |
| topic | aloe vera extract antimicrobial helicobacter pylori molecular docking |
| url | https://journals.lww.com/10.4103/abr.abr_141_24 |
| work_keys_str_mv | AT roghayehfarajnabi theinvitroantimicrobialeffectofethanolicextractsofaloeveraonthehpyloriandinhibitoryeffectofsecondarymetabolitesofaloeverabymoleculardocking AT zahrahojjatibonab theinvitroantimicrobialeffectofethanolicextractsofaloeveraonthehpyloriandinhibitoryeffectofsecondarymetabolitesofaloeverabymoleculardocking AT nedashagayegh theinvitroantimicrobialeffectofethanolicextractsofaloeveraonthehpyloriandinhibitoryeffectofsecondarymetabolitesofaloeverabymoleculardocking AT roghayehfarajnabi invitroantimicrobialeffectofethanolicextractsofaloeveraonthehpyloriandinhibitoryeffectofsecondarymetabolitesofaloeverabymoleculardocking AT zahrahojjatibonab invitroantimicrobialeffectofethanolicextractsofaloeveraonthehpyloriandinhibitoryeffectofsecondarymetabolitesofaloeverabymoleculardocking AT nedashagayegh invitroantimicrobialeffectofethanolicextractsofaloeveraonthehpyloriandinhibitoryeffectofsecondarymetabolitesofaloeverabymoleculardocking |