Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major
A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/840768 |
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| _version_ | 1850120777497575424 |
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| author | Danielle Gomes Passos-Silva Matheus Andrade Rajão Pedro Henrique Nascimento de Aguiar João Pedro Vieira-da-Rocha Carlos Renato Machado Carolina Furtado |
| author_facet | Danielle Gomes Passos-Silva Matheus Andrade Rajão Pedro Henrique Nascimento de Aguiar João Pedro Vieira-da-Rocha Carlos Renato Machado Carolina Furtado |
| author_sort | Danielle Gomes Passos-Silva |
| collection | DOAJ |
| description | A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides, and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited. Together with recent experimental studies, the genome sequencing of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, has revealed interesting features of the DNA repair mechanism in these protozoan parasites, which will be reviewed here. |
| format | Article |
| id | doaj-art-60077ccc38f94e08be6247326cf4a456 |
| institution | OA Journals |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-60077ccc38f94e08be6247326cf4a4562025-08-20T02:35:17ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/840768840768Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania majorDanielle Gomes Passos-Silva0Matheus Andrade Rajão1Pedro Henrique Nascimento de Aguiar2João Pedro Vieira-da-Rocha3Carlos Renato Machado4Carolina Furtado5Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, BrazilA wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides, and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited. Together with recent experimental studies, the genome sequencing of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, has revealed interesting features of the DNA repair mechanism in these protozoan parasites, which will be reviewed here.http://dx.doi.org/10.4061/2010/840768 |
| spellingShingle | Danielle Gomes Passos-Silva Matheus Andrade Rajão Pedro Henrique Nascimento de Aguiar João Pedro Vieira-da-Rocha Carlos Renato Machado Carolina Furtado Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major Journal of Nucleic Acids |
| title | Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major |
| title_full | Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major |
| title_fullStr | Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major |
| title_full_unstemmed | Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major |
| title_short | Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major |
| title_sort | overview of dna repair in trypanosoma cruzi trypanosoma brucei and leishmania major |
| url | http://dx.doi.org/10.4061/2010/840768 |
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