Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells
Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN-γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/849573 |
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| author | Patrícia S. de Araújo-Souza Steffi C. H. Hanschke João P. B. Viola |
| author_facet | Patrícia S. de Araújo-Souza Steffi C. H. Hanschke João P. B. Viola |
| author_sort | Patrícia S. de Araújo-Souza |
| collection | DOAJ |
| description | Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN-γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells. However, naïve CD8 T lymphocytes do not produce large amounts of IFN-γ, but after TCR stimulation there is a progressive acquisition of IFN-γ expression during differentiation into cytotoxic T lymphocytes (CTL) and memory cells, which are capable of producing high levels of this cytokine. Differential gene expression can be regulated from the selective action of transcriptional factors and also from epigenetic mechanisms, such as DNA CpG methylation or posttranslational histone modifications. Recently it has been recognized that epigenetic modification is an integral part of CD8 lymphocyte differentiation. This review will focus on the chromatin status of Ifng promoter in CD8 T cells and possible influences of epigenetic modifications in Ifng gene and conserved noncoding sequences (CNSs) in regulation of IFN-γ production by CD8 T lymphocytes. |
| format | Article |
| id | doaj-art-6006d828af264664a1eb16864eaf4079 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-6006d828af264664a1eb16864eaf40792025-02-03T01:21:14ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/849573849573Epigenetic Control of Interferon-Gamma Expression in CD8 T CellsPatrícia S. de Araújo-Souza0Steffi C. H. Hanschke1João P. B. Viola2Program of Cellular Biology, Brazilian National Cancer Institute (INCA), Rua André Cavalcanti 37, Centro, 20231-050 Rio de Janeiro, RJ, BrazilProgram of Cellular Biology, Brazilian National Cancer Institute (INCA), Rua André Cavalcanti 37, Centro, 20231-050 Rio de Janeiro, RJ, BrazilProgram of Cellular Biology, Brazilian National Cancer Institute (INCA), Rua André Cavalcanti 37, Centro, 20231-050 Rio de Janeiro, RJ, BrazilInterferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN-γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells. However, naïve CD8 T lymphocytes do not produce large amounts of IFN-γ, but after TCR stimulation there is a progressive acquisition of IFN-γ expression during differentiation into cytotoxic T lymphocytes (CTL) and memory cells, which are capable of producing high levels of this cytokine. Differential gene expression can be regulated from the selective action of transcriptional factors and also from epigenetic mechanisms, such as DNA CpG methylation or posttranslational histone modifications. Recently it has been recognized that epigenetic modification is an integral part of CD8 lymphocyte differentiation. This review will focus on the chromatin status of Ifng promoter in CD8 T cells and possible influences of epigenetic modifications in Ifng gene and conserved noncoding sequences (CNSs) in regulation of IFN-γ production by CD8 T lymphocytes.http://dx.doi.org/10.1155/2015/849573 |
| spellingShingle | Patrícia S. de Araújo-Souza Steffi C. H. Hanschke João P. B. Viola Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells Journal of Immunology Research |
| title | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
| title_full | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
| title_fullStr | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
| title_full_unstemmed | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
| title_short | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
| title_sort | epigenetic control of interferon gamma expression in cd8 t cells |
| url | http://dx.doi.org/10.1155/2015/849573 |
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