Navigating TAM receptor dynamics in tumour immunotherapy
Abstract The TAM receptor family is getting more and more attention in the field of tumour immunity. Activation of TAM receptors not only aids in the survival and multiplication of tumour cells but also increases their likelihood of invading other cells and spreading. In addition, activation of TAM...
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| Format: | Article |
| Language: | English |
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Springer
2025-03-01
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| Series: | Cancer Immunology, Immunotherapy |
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| Online Access: | https://doi.org/10.1007/s00262-024-03879-z |
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| author | Jihao Yang Guanmin Chen Rui Wang Chengcheng Song Huaqiang Yi |
| author_facet | Jihao Yang Guanmin Chen Rui Wang Chengcheng Song Huaqiang Yi |
| author_sort | Jihao Yang |
| collection | DOAJ |
| description | Abstract The TAM receptor family is getting more and more attention in the field of tumour immunity. Activation of TAM receptors not only aids in the survival and multiplication of tumour cells but also increases their likelihood of invading other cells and spreading. In addition, activation of TAM receptors helps to inhibit the anti-tumour immune response, allowing tumour cells to evade immune surveillance. In terms of therapeutic strategies, a number of inhibitors targeting TAM receptors are in preclinical and clinical development. Despite significant progress in clinical trials in recent years, challenges remain. This review delves into the kinetic characteristics of the TAM receptor family, their dual role in tumour immunity, and the transmission process of downstream signalling pathways. Based on this, we analysed and summarised the unique strategies and combination therapies for regulating tumour immunity using TAM receptor inhibitors. It not only helps to elucidate the key role of TAM receptors in tumour immunity but also provides new perspectives and strategies for future tumour therapy. |
| format | Article |
| id | doaj-art-6006ae5d9acc4df5a0c81fbb5b0ffec6 |
| institution | DOAJ |
| issn | 1432-0851 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Cancer Immunology, Immunotherapy |
| spelling | doaj-art-6006ae5d9acc4df5a0c81fbb5b0ffec62025-08-20T03:14:08ZengSpringerCancer Immunology, Immunotherapy1432-08512025-03-0174511410.1007/s00262-024-03879-zNavigating TAM receptor dynamics in tumour immunotherapyJihao Yang0Guanmin Chen1Rui Wang2Chengcheng Song3Huaqiang Yi4School of Acupuncture and Tuina, Shandong University of Traditional Chinese, MedicineSchool of Acupuncture and Tuina, Shandong University of Traditional Chinese, MedicineSchool of Acupuncture and Tuina, Shandong University of Traditional Chinese, MedicineSchool of Acupuncture and Tuina, Shandong University of Traditional Chinese, MedicineSchool of Acupuncture and Tuina, Shandong University of Traditional Chinese, MedicineAbstract The TAM receptor family is getting more and more attention in the field of tumour immunity. Activation of TAM receptors not only aids in the survival and multiplication of tumour cells but also increases their likelihood of invading other cells and spreading. In addition, activation of TAM receptors helps to inhibit the anti-tumour immune response, allowing tumour cells to evade immune surveillance. In terms of therapeutic strategies, a number of inhibitors targeting TAM receptors are in preclinical and clinical development. Despite significant progress in clinical trials in recent years, challenges remain. This review delves into the kinetic characteristics of the TAM receptor family, their dual role in tumour immunity, and the transmission process of downstream signalling pathways. Based on this, we analysed and summarised the unique strategies and combination therapies for regulating tumour immunity using TAM receptor inhibitors. It not only helps to elucidate the key role of TAM receptors in tumour immunity but also provides new perspectives and strategies for future tumour therapy.https://doi.org/10.1007/s00262-024-03879-zTAM receptorTYRO3AXLMERTKTumour |
| spellingShingle | Jihao Yang Guanmin Chen Rui Wang Chengcheng Song Huaqiang Yi Navigating TAM receptor dynamics in tumour immunotherapy Cancer Immunology, Immunotherapy TAM receptor TYRO3 AXL MERTK Tumour |
| title | Navigating TAM receptor dynamics in tumour immunotherapy |
| title_full | Navigating TAM receptor dynamics in tumour immunotherapy |
| title_fullStr | Navigating TAM receptor dynamics in tumour immunotherapy |
| title_full_unstemmed | Navigating TAM receptor dynamics in tumour immunotherapy |
| title_short | Navigating TAM receptor dynamics in tumour immunotherapy |
| title_sort | navigating tam receptor dynamics in tumour immunotherapy |
| topic | TAM receptor TYRO3 AXL MERTK Tumour |
| url | https://doi.org/10.1007/s00262-024-03879-z |
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