Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia
In this study, we investigated the association between the plasma NT-proBNP level at admission and the severity of COVID-19 pneumonia. For this retrospective, single-centre cohort study, we enrolled consecutive patients from February 9 to March 4, 2020, in a COVID-19 ward of Hubei General Hospital (...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/5537275 |
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| author | Lan Wang Fei Chen Lin Bai Lang Bai Zhixin Huang Yong Peng |
| author_facet | Lan Wang Fei Chen Lin Bai Lang Bai Zhixin Huang Yong Peng |
| author_sort | Lan Wang |
| collection | DOAJ |
| description | In this study, we investigated the association between the plasma NT-proBNP level at admission and the severity of COVID-19 pneumonia. For this retrospective, single-centre cohort study, we enrolled consecutive patients from February 9 to March 4, 2020, in a COVID-19 ward of Hubei General Hospital (East Branch) in Wuhan, which is a government-assigned centre for COVID-19 treatment. Diagnosis was confirmed by microbiological and radiographic findings following the interim guidance of the World Health Organization (WHO). A total of 91 (92.9%) patients were finally included in this study. The median age of the patients was 61 years (IQR, 47–69), and 39 (43.0%) of them were male. Two cases of death were reported (2.3%). Twenty-three patients (25.3%) had NT-proBNP levels above 300 pg/ml. Higher NT-proBNP levels were associated with worse PSI and CT scores. The natural logarithm of the NT-proBNP level was positively correlated with the PSI and CT scores (PSI score: rS = 0.396, P=0.001; CT score: rS = 0.440, P<0.001). Patients with NT-proBNP ≥300 pg/ml showed a potential risk for higher mortality than patients with NT-proBNP <300 pg/ml (mortality rate, 8.7% vs. 0%; P=0.062). The plasma NT-proBNP level of COVID-19 patients was significantly related to the severity of pneumonia. |
| format | Article |
| id | doaj-art-5ffc6e9f671b4195b12c053c273bf097 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-5ffc6e9f671b4195b12c053c273bf0972025-02-03T05:45:20ZengWileyCardiology Research and Practice2090-80162090-05972021-01-01202110.1155/2021/55372755537275Association between NT-proBNP Level and the Severity of COVID-19 PneumoniaLan Wang0Fei Chen1Lin Bai2Lang Bai3Zhixin Huang4Yong Peng5Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaMedical Team from West China Hospital of Sichuan University in Hubei General Hospital (East Branch), Wuhan, ChinaHubei General Hospital (East Branch) & Renmin Hospital of Wuhan University, Wuhan, ChinaMedical Team from West China Hospital of Sichuan University in Hubei General Hospital (East Branch), Wuhan, ChinaIn this study, we investigated the association between the plasma NT-proBNP level at admission and the severity of COVID-19 pneumonia. For this retrospective, single-centre cohort study, we enrolled consecutive patients from February 9 to March 4, 2020, in a COVID-19 ward of Hubei General Hospital (East Branch) in Wuhan, which is a government-assigned centre for COVID-19 treatment. Diagnosis was confirmed by microbiological and radiographic findings following the interim guidance of the World Health Organization (WHO). A total of 91 (92.9%) patients were finally included in this study. The median age of the patients was 61 years (IQR, 47–69), and 39 (43.0%) of them were male. Two cases of death were reported (2.3%). Twenty-three patients (25.3%) had NT-proBNP levels above 300 pg/ml. Higher NT-proBNP levels were associated with worse PSI and CT scores. The natural logarithm of the NT-proBNP level was positively correlated with the PSI and CT scores (PSI score: rS = 0.396, P=0.001; CT score: rS = 0.440, P<0.001). Patients with NT-proBNP ≥300 pg/ml showed a potential risk for higher mortality than patients with NT-proBNP <300 pg/ml (mortality rate, 8.7% vs. 0%; P=0.062). The plasma NT-proBNP level of COVID-19 patients was significantly related to the severity of pneumonia.http://dx.doi.org/10.1155/2021/5537275 |
| spellingShingle | Lan Wang Fei Chen Lin Bai Lang Bai Zhixin Huang Yong Peng Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia Cardiology Research and Practice |
| title | Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia |
| title_full | Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia |
| title_fullStr | Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia |
| title_full_unstemmed | Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia |
| title_short | Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia |
| title_sort | association between nt probnp level and the severity of covid 19 pneumonia |
| url | http://dx.doi.org/10.1155/2021/5537275 |
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