Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure

Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure

Abstract Background Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response. Research has been conducted to elucidate...

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Bibliographic Details
Main Authors: Jing Yan, Yifeng Pan, Chaoqi Chen, Lijian Liu, Jinjing Tan, Juan Li, Liqun Li, Sheng Xie
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Hereditas
Subjects:
Sepsis
Acute liver failure
Pyroptosis
Immune cell infiltration
Animal experimental validation
Online Access:https://doi.org/10.1186/s41065-025-00522-4
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