Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform?
Wound reepithelialization is a cooperative multifactorial process dominated by keratinocyte migration, proliferation, and differentiation that restores the intact epidermal barrier to prevent infection and excessive moisture loss. However, in wounds that exhibit impaired wound healing, such as chron...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6120173 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850157949630021632 |
|---|---|
| author | Deyun Chen Haojie Hao Xiaobing Fu Weidong Han |
| author_facet | Deyun Chen Haojie Hao Xiaobing Fu Weidong Han |
| author_sort | Deyun Chen |
| collection | DOAJ |
| description | Wound reepithelialization is a cooperative multifactorial process dominated by keratinocyte migration, proliferation, and differentiation that restores the intact epidermal barrier to prevent infection and excessive moisture loss. However, in wounds that exhibit impaired wound healing, such as chronic nonhealing wounds or hypertrophic scars, the reepithelialization process has failed. Thus, it is necessary to explore a suitable way to mitigate these abnormalities to promote reepithelialization and achieve wound healing. Mesenchymal stem cells (MSCs) have the capacity for self-renewal as well as potential multipotency. These cells play important roles in many biological processes, including anti-inflammation, cell migration, proliferation, and differentiation, and signal pathway activation or inhibition. The mechanism of the involvement of MSCs in reepithelialization is still not fully understood. An abundance of evidence has shown that MSCs participate in reepithelialization by inhibiting excessive inflammatory responses, secreting important factors, differentiating into multiple skin cell types, and recruiting other host cells. This review describes the evidence for the roles that MSCs appear to play in the reepithelialization process. |
| format | Article |
| id | doaj-art-5fef5d6ec2f741db94cb445e69593701 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5fef5d6ec2f741db94cb445e695937012025-08-20T02:24:00ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/61201736120173Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform?Deyun Chen0Haojie Hao1Xiaobing Fu2Weidong Han3Institute of Basic Medicine Science, Chinese PLA General Hospital, Beijing 100853, ChinaInstitute of Basic Medicine Science, Chinese PLA General Hospital, Beijing 100853, ChinaInstitute of Basic Medicine Science, Chinese PLA General Hospital, Beijing 100853, ChinaInstitute of Basic Medicine Science, Chinese PLA General Hospital, Beijing 100853, ChinaWound reepithelialization is a cooperative multifactorial process dominated by keratinocyte migration, proliferation, and differentiation that restores the intact epidermal barrier to prevent infection and excessive moisture loss. However, in wounds that exhibit impaired wound healing, such as chronic nonhealing wounds or hypertrophic scars, the reepithelialization process has failed. Thus, it is necessary to explore a suitable way to mitigate these abnormalities to promote reepithelialization and achieve wound healing. Mesenchymal stem cells (MSCs) have the capacity for self-renewal as well as potential multipotency. These cells play important roles in many biological processes, including anti-inflammation, cell migration, proliferation, and differentiation, and signal pathway activation or inhibition. The mechanism of the involvement of MSCs in reepithelialization is still not fully understood. An abundance of evidence has shown that MSCs participate in reepithelialization by inhibiting excessive inflammatory responses, secreting important factors, differentiating into multiple skin cell types, and recruiting other host cells. This review describes the evidence for the roles that MSCs appear to play in the reepithelialization process.http://dx.doi.org/10.1155/2016/6120173 |
| spellingShingle | Deyun Chen Haojie Hao Xiaobing Fu Weidong Han Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform? Stem Cells International |
| title | Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform? |
| title_full | Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform? |
| title_fullStr | Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform? |
| title_full_unstemmed | Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform? |
| title_short | Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform? |
| title_sort | insight into reepithelialization how do mesenchymal stem cells perform |
| url | http://dx.doi.org/10.1155/2016/6120173 |
| work_keys_str_mv | AT deyunchen insightintoreepithelializationhowdomesenchymalstemcellsperform AT haojiehao insightintoreepithelializationhowdomesenchymalstemcellsperform AT xiaobingfu insightintoreepithelializationhowdomesenchymalstemcellsperform AT weidonghan insightintoreepithelializationhowdomesenchymalstemcellsperform |