Impact of Genetic Variants on Pregabalin Pharmacokinetics and Safety

Impact of Genetic Variants on Pregabalin Pharmacokinetics and Safety

<b>Background/Objectives:</b> Pregabalin is a useful therapeutic option for patients with anxiety or neuropathic pain. Genetic variants in certain genes encoding for transporters related to absorption and distribution could have an impact on the efficacy and safety of the drug. Furthermo...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sofía Calleja, Andrea Rodríguez-López, Dolores Ochoa, Sergio Luquero, Marcos Navares-Gómez, Manuel Román, Gina Mejia-Abril, Samuel Martín-Vilchez, Francisco Abad-Santos, Pablo Zubiaur
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Pharmaceuticals
Subjects:	pregabalin pharmacokinetics safety pharmacogenetics
Online Access:	https://www.mdpi.com/1424-8247/18/2/151
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Treatment of Fibromyalgia - duloxetine or pregabalin?
by: Magdalena Bujak, et al.
Published: (2025-04-01)

Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series
by: Aaliya Khanam, et al.
Published: (2025-01-01)

PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus)
by: Wissam Sajid Hashim Al-Uboody
Published: (2017-12-01)

9-PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus)
by: Wissam Sajid Hashim Al-Uboody
Published: (2018-06-01)

Pathological effects of pregabalin toxicity in rats
by: Roaa Salih Mahdi, et al.
Published: (2024-01-01)

KT-PERFUSION DYNAMICS OF A BRAIN AT PATIENTS WITH SYMPTOMATIC EPILEPSY AT TREATMENT WITH PREGABALIN
by: A. S. Shershever, et al.
Published: (2016-09-01)

Investigation of the <i>ABCB1</i> Gene Polymorphism and Food Effects on the Avatrombopag Pharmacokinetics in Chinese Individuals: A Population Pharmacokinetic/Pharmacodynamic Analysis
by: Xin Liu, et al.
Published: (2025-06-01)

Comparing the effectiveness of pregabalin and duloxetine in the management of neuropathic pain
by: Rojgar Hamed Ali, et al.
Published: (2025-04-01)

Pregabalin abuse in adolescence: a case series
by: Burcu Ersöz Alan, et al.
Published: (2022-04-01)

Pregabalin use in HIV-infected patients with opioid dependence syndrome
by: M. Ya. Kissin, et al.
Published: (2018-11-01)

Preoperative pregabalin to prevent postoperative nausea and vomiting in laparoscopic cholecystectomy
by: A. A. Sahib, et al.
Published: (2023-02-01)

Incidence of somnolence and dizziness induced by mirogabalin and pregabalin under opioid treatment: a single-center observational study
by: Hitoshi Iwasaki, et al.
Published: (2025-07-01)

The effects of preoperative pregabalin administration on postoperative pain on Libyan patients undergoing laparoscopic cholecystectomy
by: Munira Elmansouri, et al.
Published: (2018-07-01)

Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers
by: Alexander Lenard, et al.
Published: (2025-04-01)

Pharmacokinetics of Pentanedioic Acid Imidazolyl Ethanamide in Healthy Volunteers
by: I. G. Gordeev, et al.
Published: (2021-05-01)

PREGABALIN AND ALPRAZOLAM IN TREATMENT OF GENERALIZED ANXIETY DISORDER IN PATIENTS WITH PARTIAL EPILEPSY
by: M. Ya. Kissin, et al.
Published: (2016-08-01)

PREGABALIN AND ALPRAZOLAM IN TREATMENT OF GENERALIZED ANXIETY DISORDER IN PATIENTS WITH PARTIAL EPILEPSY
by: M. Ya. Kissin, et al.
Published: (2016-08-01)

Pharmacogenetics and pharmacokinetics of rivaroxaban in patients with atrial fibrillation and chronic kidney disease
by: N. A. Shatalova, et al.
Published: (2023-11-01)

Pregabalin Safety in Pregnancy: A Disproportionality Analysis of VigiBase Spontaneous Reporting System
by: Sarah Mondada, et al.
Published: (2025-05-01)

Investigation of illicit pregabalin in seized samples from Saudi Arabia
by: Fatimah M. Alamri, et al.
Published: (2025-07-01)

A comparative study of the effectiveness and safety of pregabalin and duloxetine in the treatment of chemotherapy-induced neuropathic pain
by: Yogendra Singhal, et al.
Published: (2025-01-01)

Evaluation of Oral Pregabalin Premedication for Attenuation of Haemodynamic Response during Tracheal Intubation in Adult Patients with Controlled Hypertension For Elective Surgery
by: Surabhi Sandill, et al.
Published: (2024-09-01)

Correction: Investigation of illicit pregabalin in seized samples from Saudi Arabia
by: Frontiers Production Office
Published: (2025-08-01)

The impact of pregabalin and gabapentin on essential tremor: a systematic review and meta-analysis
by: Hooman Pourbala, et al.
Published: (2025-01-01)

Donor and recipient genetic variants in drug metabolizing enzymes and transporters affect early tacrolimus pharmacokinetics after liver transplantation
by: Alexandra D. Ladd, et al.
Published: (2025-07-01)

Is perioperative use of a combination of pregabalin and naproxen superior to naproxen only in reducing pain in ankle fractures? A prospective, randomized, multicenter study
by: Gi Won Choi, et al.
Published: (2024-12-01)

Development and validation of a population pharmacokinetic model to guide perioperative tacrolimus dosing after lung transplantation
by: Todd A. Miano, PharmD, PhD, et al.
Published: (2024-11-01)

Association of perioperative initiation of gabapentin versus pregabalin with kidney function: a target trial emulation study
by: Yanfang He, et al.
Published: (2024-12-01)

Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety
by: Víctor Mayoral, et al.
Published: (2025-01-01)

Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients
by: Lesly Yanira Xajil-Ramos, et al.
Published: (2025-05-01)

The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy
by: A. S. Shershever, et al.
Published: (2016-08-01)

Restless Legs Syndrome Patients with Early Onset Disease or a Relevant Family History Associated with Pramipexole Ineffectiveness but Not Pregabalin
by: Ying M, et al.
Published: (2025-07-01)

Pregabalin and gabapentin for chronic low back pain without radiculopathy: a systematic review
by: Rafael Trindade Tatit, et al.
Published: (2023-06-01)

New Pharmacological Insight into Etanercept and Pregabalin in Allodynia and Nociception: Behavioral Studies in a Murine Neuropathic Pain Model
by: Loulwah Alothman, et al.
Published: (2024-11-01)

Examination of optical coherence tomography findings in patients with pregabalin use disorder
by: Osman Hasan Tahsin Kılıç, et al.
Published: (2024-11-01)

PHARMACOKINETIC AND PHARMACOGENETIC ASPECTS OF PERSONALIZED ANALGETIC THERAPY WITH FENTANIL TTS IN CLINICAL ONCOLOGY
by: O. P. Bobrova, et al.
Published: (2018-07-01)

Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain
by: Swati Dogra, et al.
Published: (2025-05-01)

CYP3A Genotype Is Associated With Variability in the Exposure and Clearance of the Novel Oncogenic Transcription Inhibitor Lurbinectedin
by: Rubin Lubomirov, et al.
Published: (2025-04-01)

Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness
by: Narcis Cardoner, et al.
Published: (2025-02-01)

Case Report: Synergistic central nervous system depression of baclofen and pregabalin: clinical pharmacist-driven case analysis and case review
by: Yitong Xie, et al.
Published: (2025-06-01)