Giant Cell Urothelial Carcinoma of Bladder
Giant cell urothelial carcinoma is a rare variant of bladder cancer recognized by the current World Health Organization classification of urologic tumours. It is an aggressive tumour with a poor prognosis that usually presents at an advanced stage. It is characterized histologically by pleomorphic g...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2021/8021947 |
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| _version_ | 1850159048859582464 |
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| author | Harshima Disvini Wijesinghe Ajith Malalasekera |
| author_facet | Harshima Disvini Wijesinghe Ajith Malalasekera |
| author_sort | Harshima Disvini Wijesinghe |
| collection | DOAJ |
| description | Giant cell urothelial carcinoma is a rare variant of bladder cancer recognized by the current World Health Organization classification of urologic tumours. It is an aggressive tumour with a poor prognosis that usually presents at an advanced stage. It is characterized histologically by pleomorphic giant cells. We discuss a case of giant cell urothelial carcinoma presenting at an early stage in a previously well 62-year-old woman. Histology showed a tumour comprising pancytokeratin positive bizarre mononuclear and multi-nuclear giant cells admixed with areas of conventional urothelial carcinoma and carcinoma in situ. Three-month follow-up cystoscopy and magnetic resonance imaging showed no evidence of recurrence or pelvic lymphadenopathy. |
| format | Article |
| id | doaj-art-5fec3ef899374b66aed96fe45eca8de6 |
| institution | OA Journals |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-5fec3ef899374b66aed96fe45eca8de62025-08-20T02:23:40ZengWileyCase Reports in Urology2090-696X2090-69782021-01-01202110.1155/2021/80219478021947Giant Cell Urothelial Carcinoma of BladderHarshima Disvini Wijesinghe0Ajith Malalasekera1Department of Pathology, Faculty of Medicine, University of Colombo, Sri LankaDepartment of Anatomy, Faculty of Medicine, University of Colombo, Sri LankaGiant cell urothelial carcinoma is a rare variant of bladder cancer recognized by the current World Health Organization classification of urologic tumours. It is an aggressive tumour with a poor prognosis that usually presents at an advanced stage. It is characterized histologically by pleomorphic giant cells. We discuss a case of giant cell urothelial carcinoma presenting at an early stage in a previously well 62-year-old woman. Histology showed a tumour comprising pancytokeratin positive bizarre mononuclear and multi-nuclear giant cells admixed with areas of conventional urothelial carcinoma and carcinoma in situ. Three-month follow-up cystoscopy and magnetic resonance imaging showed no evidence of recurrence or pelvic lymphadenopathy.http://dx.doi.org/10.1155/2021/8021947 |
| spellingShingle | Harshima Disvini Wijesinghe Ajith Malalasekera Giant Cell Urothelial Carcinoma of Bladder Case Reports in Urology |
| title | Giant Cell Urothelial Carcinoma of Bladder |
| title_full | Giant Cell Urothelial Carcinoma of Bladder |
| title_fullStr | Giant Cell Urothelial Carcinoma of Bladder |
| title_full_unstemmed | Giant Cell Urothelial Carcinoma of Bladder |
| title_short | Giant Cell Urothelial Carcinoma of Bladder |
| title_sort | giant cell urothelial carcinoma of bladder |
| url | http://dx.doi.org/10.1155/2021/8021947 |
| work_keys_str_mv | AT harshimadisviniwijesinghe giantcellurothelialcarcinomaofbladder AT ajithmalalasekera giantcellurothelialcarcinomaofbladder |