Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women
The aim of this study was to determine the effects of resistance training on the immunologic response, body composition, tumor necrosis factor-alpha (TNF-alpha) gene expression obtained from blood leukocytes, and the cytokines interleukin-6, TNF-alpha, and C-reactive protein (CRP), in the elderly wo...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1467025 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850159131588034560 |
|---|---|
| author | Luís Ângelo Macêdo Santiago Lídio Gonçalves Lima Neto Guilherme Borges Pereira Richard Diego Leite Cristiano Texeira Mostarda Janaina de Oliveira Brito Monzani Wandson Rodrigues Sousa Aruanã Joaquim Matheus Rodrigues Pinheiro Francisco Navarro |
| author_facet | Luís Ângelo Macêdo Santiago Lídio Gonçalves Lima Neto Guilherme Borges Pereira Richard Diego Leite Cristiano Texeira Mostarda Janaina de Oliveira Brito Monzani Wandson Rodrigues Sousa Aruanã Joaquim Matheus Rodrigues Pinheiro Francisco Navarro |
| author_sort | Luís Ângelo Macêdo Santiago |
| collection | DOAJ |
| description | The aim of this study was to determine the effects of resistance training on the immunologic response, body composition, tumor necrosis factor-alpha (TNF-alpha) gene expression obtained from blood leukocytes, and the cytokines interleukin-6, TNF-alpha, and C-reactive protein (CRP), in the elderly women (mean age 63 ± 2 y). A randomized controlled trial was performed using a bi-set training method for eight weeks in nineteen elderly women. Peripheral blood samples were collected by puncture in pretraining (Pre) and posttraining (Post) moments. In the resistance training group, there was a statistically significant decrease from 38.43 ± 9.48 pg/mL to 11.76 ± 5.19 pg/mL (p=0.01) in the serum levels of interleukin-6. Considering serum levels of TNF-alpha, there was a statistically significant difference, comparing the resistance training group at Pre (66.27 ± 10.31 pg/mL) and Post (37.85 ± 9.05 pg/mL) moments (p=0.01). In molecular analysis of TNF-alpha gene expression, there was a statistically significant decrease (p=0.007) between Pre (0.010 ± 0.01 ng/ml) and Post (0.0002 ± 0.0001 ng/ml) moments. Among CRP data, in the resistance training group, there was a statistically significant reduction, between Pre (2.04 ± 0.32 mg/L) and Post (0.90 ± 0.22 mg/L) moments (p=0.001). In the Control group, there was no statistical significance between these two moments. Therefore, the resistance training demonstrated changes in the TNF-alpha gene expression in elderly women, as well as decreased serum levels of interleukin-6, TNF-alpha, and CRP. Such conditions may be related to immune modulation and anti-inflammatory effects, since resistance training releases cytokines, especially interleukin-6, which acts as a TNF-alpha antagonist during exercise. |
| format | Article |
| id | doaj-art-5fe7628c847746b4b59588f5e104e4d1 |
| institution | OA Journals |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-5fe7628c847746b4b59588f5e104e4d12025-08-20T02:23:40ZengWileyJournal of Aging Research2090-22042090-22122018-01-01201810.1155/2018/14670251467025Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly WomenLuís Ângelo Macêdo Santiago0Lídio Gonçalves Lima Neto1Guilherme Borges Pereira2Richard Diego Leite3Cristiano Texeira Mostarda4Janaina de Oliveira Brito Monzani5Wandson Rodrigues Sousa6Aruanã Joaquim Matheus Rodrigues Pinheiro7Francisco Navarro8Department of Medicine, Federal University of Maranhão (UFMA), Pinheiro, MA, BrazilLaboratory of Immunology and Microbiology of Respiratory Infections, LAMIR, Universidade CEUMA, São Luis, MA, BrazilUndergraduate Program in Physical Education at the Catholic University of Brasilia, Brasília, BrazilDepartment of Physical Education, Federal University of Espírito Santo (UFES), Vitória, ES, BrazilDepartment of Physical Education, Federal University of Maranhão (UFMA), São Luis, MA, BrazilDepartment of Physical Education, Federal University of Maranhão (UFMA), São Luis, MA, BrazilPostgraduate Program in Adult and Child Health, PPGSAC, UFMA, São Luis, MA, BrazilLaboratory of Immunology and Microbiology of Respiratory Infections, LAMIR, Universidade CEUMA, São Luis, MA, BrazilDepartment of Physical Education, Federal University of Maranhão (UFMA), São Luis, MA, BrazilThe aim of this study was to determine the effects of resistance training on the immunologic response, body composition, tumor necrosis factor-alpha (TNF-alpha) gene expression obtained from blood leukocytes, and the cytokines interleukin-6, TNF-alpha, and C-reactive protein (CRP), in the elderly women (mean age 63 ± 2 y). A randomized controlled trial was performed using a bi-set training method for eight weeks in nineteen elderly women. Peripheral blood samples were collected by puncture in pretraining (Pre) and posttraining (Post) moments. In the resistance training group, there was a statistically significant decrease from 38.43 ± 9.48 pg/mL to 11.76 ± 5.19 pg/mL (p=0.01) in the serum levels of interleukin-6. Considering serum levels of TNF-alpha, there was a statistically significant difference, comparing the resistance training group at Pre (66.27 ± 10.31 pg/mL) and Post (37.85 ± 9.05 pg/mL) moments (p=0.01). In molecular analysis of TNF-alpha gene expression, there was a statistically significant decrease (p=0.007) between Pre (0.010 ± 0.01 ng/ml) and Post (0.0002 ± 0.0001 ng/ml) moments. Among CRP data, in the resistance training group, there was a statistically significant reduction, between Pre (2.04 ± 0.32 mg/L) and Post (0.90 ± 0.22 mg/L) moments (p=0.001). In the Control group, there was no statistical significance between these two moments. Therefore, the resistance training demonstrated changes in the TNF-alpha gene expression in elderly women, as well as decreased serum levels of interleukin-6, TNF-alpha, and CRP. Such conditions may be related to immune modulation and anti-inflammatory effects, since resistance training releases cytokines, especially interleukin-6, which acts as a TNF-alpha antagonist during exercise.http://dx.doi.org/10.1155/2018/1467025 |
| spellingShingle | Luís Ângelo Macêdo Santiago Lídio Gonçalves Lima Neto Guilherme Borges Pereira Richard Diego Leite Cristiano Texeira Mostarda Janaina de Oliveira Brito Monzani Wandson Rodrigues Sousa Aruanã Joaquim Matheus Rodrigues Pinheiro Francisco Navarro Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women Journal of Aging Research |
| title | Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women |
| title_full | Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women |
| title_fullStr | Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women |
| title_full_unstemmed | Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women |
| title_short | Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women |
| title_sort | effects of resistance training on immunoinflammatory response tnf alpha gene expression and body composition in elderly women |
| url | http://dx.doi.org/10.1155/2018/1467025 |
| work_keys_str_mv | AT luisangelomacedosantiago effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen AT lidiogoncalveslimaneto effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen AT guilhermeborgespereira effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen AT richarddiegoleite effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen AT cristianotexeiramostarda effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen AT janainadeoliveirabritomonzani effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen AT wandsonrodriguessousa effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen AT aruanajoaquimmatheusrodriguespinheiro effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen AT francisconavarro effectsofresistancetrainingonimmunoinflammatoryresponsetnfalphageneexpressionandbodycompositioninelderlywomen |