A Case Report and Literature Review on Systemic Sclerosis Manifesting as Melena and Hematochezia

Systemic sclerosis (SSc) is a rare autoimmune disorder that leads to progressive fibrosis and vascular dysfunction, frequently affecting the gastrointestinal tract with around 90% of patients experiencing gastrointestinal complications, with severe manifestations such as gastric antral vascular ecta...

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Main Authors: Anthony El Gharib MD, Léa Nassif MD, Karam Karam MD, Elias Fiani MD
Format: Article
Language:English
Published: SAGE Publishing 2025-06-01
Series:Journal of Investigative Medicine High Impact Case Reports
Online Access:https://doi.org/10.1177/23247096251348903
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author Anthony El Gharib MD
Léa Nassif MD
Karam Karam MD
Elias Fiani MD
author_facet Anthony El Gharib MD
Léa Nassif MD
Karam Karam MD
Elias Fiani MD
author_sort Anthony El Gharib MD
collection DOAJ
description Systemic sclerosis (SSc) is a rare autoimmune disorder that leads to progressive fibrosis and vascular dysfunction, frequently affecting the gastrointestinal tract with around 90% of patients experiencing gastrointestinal complications, with severe manifestations such as gastric antral vascular ectasia and rectal telangiectasia which lead to chronic bleeding and iron-deficiency anemia. This review and case report explore the pathophysiology of GI involvement in SSc, emphasizing fibrosis, microvascular damage, and dysmotility. It also highlights treatment options, including endoscopic interventions like argon plasma coagulation and pharmacological therapies.
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issn 2324-7096
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publisher SAGE Publishing
record_format Article
series Journal of Investigative Medicine High Impact Case Reports
spelling doaj-art-5fe5ce8f63ce4143b37ea5e3999317322025-08-20T03:21:47ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962025-06-011310.1177/23247096251348903A Case Report and Literature Review on Systemic Sclerosis Manifesting as Melena and HematocheziaAnthony El Gharib MD0Léa Nassif MD1Karam Karam MD2Elias Fiani MD3University of Balamand, Beirut, LebanonUniversity of Balamand, Beirut, LebanonUniversity of Balamand, Beirut, LebanonUniversity of Balamand, Beirut, LebanonSystemic sclerosis (SSc) is a rare autoimmune disorder that leads to progressive fibrosis and vascular dysfunction, frequently affecting the gastrointestinal tract with around 90% of patients experiencing gastrointestinal complications, with severe manifestations such as gastric antral vascular ectasia and rectal telangiectasia which lead to chronic bleeding and iron-deficiency anemia. This review and case report explore the pathophysiology of GI involvement in SSc, emphasizing fibrosis, microvascular damage, and dysmotility. It also highlights treatment options, including endoscopic interventions like argon plasma coagulation and pharmacological therapies.https://doi.org/10.1177/23247096251348903
spellingShingle Anthony El Gharib MD
Léa Nassif MD
Karam Karam MD
Elias Fiani MD
A Case Report and Literature Review on Systemic Sclerosis Manifesting as Melena and Hematochezia
Journal of Investigative Medicine High Impact Case Reports
title A Case Report and Literature Review on Systemic Sclerosis Manifesting as Melena and Hematochezia
title_full A Case Report and Literature Review on Systemic Sclerosis Manifesting as Melena and Hematochezia
title_fullStr A Case Report and Literature Review on Systemic Sclerosis Manifesting as Melena and Hematochezia
title_full_unstemmed A Case Report and Literature Review on Systemic Sclerosis Manifesting as Melena and Hematochezia
title_short A Case Report and Literature Review on Systemic Sclerosis Manifesting as Melena and Hematochezia
title_sort case report and literature review on systemic sclerosis manifesting as melena and hematochezia
url https://doi.org/10.1177/23247096251348903
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