Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide. The pan-immune-inflammation value (PIV) has been proposed as a biomarker for assessing immune status and inflammation. There is currently no evidence regar...
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BMC
2025-01-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-024-03584-2 |
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| author | Lian-Zhen Huang Ze-Bin Ni Qi-Rong Yao Wei-Feng Huang Ji Li Yan-Qing Wang Jin-Yan Zhang |
| author_facet | Lian-Zhen Huang Ze-Bin Ni Qi-Rong Yao Wei-Feng Huang Ji Li Yan-Qing Wang Jin-Yan Zhang |
| author_sort | Lian-Zhen Huang |
| collection | DOAJ |
| description | Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide. The pan-immune-inflammation value (PIV) has been proposed as a biomarker for assessing immune status and inflammation. There is currently no evidence regarding the effect of PIV on the risk of MASLD. This study aimed to investigate the association between PIV and MASLD. Methods The cross-sectional study included 6462 adults aged ≥ 20 years from the National Health and Nutrition Examination Survey 2017–2020. PIV was calculated based on blood count data. Weighted multivariable logistic regression was employed to calculate the odds ratio (OR) and 95% confidence interval (CI) to investigate the association of PIV and MASLD. Restricted cubic spline (RCS) analysis was conducted to explore the dose-response relationship between PIV and MASLD. Stratified and sensitivity analyses were performed to confirm the robustness of our findings. Results Among 6462 participants, 2458 were diagnosed with MASLD. Positive associations between LnPIV and MASLD were observed in all three models (Model 1: OR = 1.46, 95% CI: 1.28–1.66, P < 0.001; Model 2: OR = 1.41, 95% CI: 1.24–1.60, P < 0.001; Model 3: OR = 1.39, 95% CI: 1.16–1.65, P = 0.004). When PIV was classified into quartiles, both Q3 and Q4 exhibited significantly increased risks of MASLD compared with the reference Q1 in full adjusted Model 3 (Q3: OR = 1.63, 95% CI: 1.20–2.22, P = 0.012; Q4: OR = 1.76, 95% CI: 1.28–2.41, P = 0.008; P for trend = 0.002). RCS analysis did not show a nonlinear relationship between LnPIV and MASLD (P = 0.093 for nonlinearity). Stratified analysis showed a consistent positive association between LnPIV and MASLD in all subgroups, and sensitivity analyses supported the reliability of these results. Conclusions Higher PIV levels are significantly associated with an increased prevalence of MASLD, indicating that PIV is a potentially effective inflammatory marker for assessing MASLD in participants. |
| format | Article |
| id | doaj-art-5fe5539b74f4486bb8e7cbf654a4e186 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-5fe5539b74f4486bb8e7cbf654a4e1862025-01-05T12:32:02ZengBMCBMC Gastroenterology1471-230X2025-01-0125111010.1186/s12876-024-03584-2Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020Lian-Zhen Huang0Ze-Bin Ni1Qi-Rong Yao2Wei-Feng Huang3Ji Li4Yan-Qing Wang5Jin-Yan Zhang6Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Ultrasound, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityAbstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide. The pan-immune-inflammation value (PIV) has been proposed as a biomarker for assessing immune status and inflammation. There is currently no evidence regarding the effect of PIV on the risk of MASLD. This study aimed to investigate the association between PIV and MASLD. Methods The cross-sectional study included 6462 adults aged ≥ 20 years from the National Health and Nutrition Examination Survey 2017–2020. PIV was calculated based on blood count data. Weighted multivariable logistic regression was employed to calculate the odds ratio (OR) and 95% confidence interval (CI) to investigate the association of PIV and MASLD. Restricted cubic spline (RCS) analysis was conducted to explore the dose-response relationship between PIV and MASLD. Stratified and sensitivity analyses were performed to confirm the robustness of our findings. Results Among 6462 participants, 2458 were diagnosed with MASLD. Positive associations between LnPIV and MASLD were observed in all three models (Model 1: OR = 1.46, 95% CI: 1.28–1.66, P < 0.001; Model 2: OR = 1.41, 95% CI: 1.24–1.60, P < 0.001; Model 3: OR = 1.39, 95% CI: 1.16–1.65, P = 0.004). When PIV was classified into quartiles, both Q3 and Q4 exhibited significantly increased risks of MASLD compared with the reference Q1 in full adjusted Model 3 (Q3: OR = 1.63, 95% CI: 1.20–2.22, P = 0.012; Q4: OR = 1.76, 95% CI: 1.28–2.41, P = 0.008; P for trend = 0.002). RCS analysis did not show a nonlinear relationship between LnPIV and MASLD (P = 0.093 for nonlinearity). Stratified analysis showed a consistent positive association between LnPIV and MASLD in all subgroups, and sensitivity analyses supported the reliability of these results. Conclusions Higher PIV levels are significantly associated with an increased prevalence of MASLD, indicating that PIV is a potentially effective inflammatory marker for assessing MASLD in participants.https://doi.org/10.1186/s12876-024-03584-2Pan-immune-inflammatory valueNHANESMASLDCross-sectional studyInflammation |
| spellingShingle | Lian-Zhen Huang Ze-Bin Ni Qi-Rong Yao Wei-Feng Huang Ji Li Yan-Qing Wang Jin-Yan Zhang Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020 BMC Gastroenterology Pan-immune-inflammatory value NHANES MASLD Cross-sectional study Inflammation |
| title | Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020 |
| title_full | Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020 |
| title_fullStr | Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020 |
| title_full_unstemmed | Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020 |
| title_short | Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020 |
| title_sort | association of pan immune inflammatory value with metabolic dysfunction associated steatotic liver disease findings from nhanes 2017 2020 |
| topic | Pan-immune-inflammatory value NHANES MASLD Cross-sectional study Inflammation |
| url | https://doi.org/10.1186/s12876-024-03584-2 |
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