Medicarpin induces G1 arrest and mitochondria-mediated intrinsic apoptotic pathway in bladder cancer cells

Medicarpin induces G1 arrest and mitochondria-mediated intrinsic apoptotic pathway in bladder cancer cells

Bladder cancer (BC) is the tenth most commonly diagnosed cancer. High recurrence, chemoresistance, and low response rate hinder the effective treatment of BC. Hence, a novel therapeutic strategy in the clinical management of BC is urgently needed. Medicarpin (MED), an isoflavone from Dalbergia odori...

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Main Authors: Chen Yuan, Yin Liqi, Hao Mingxuan, Xu Wenkai, Gao Jixian, Sun Yuxin, Wang Qiao, Chen Shi, Liang Youfeng, Guo Rui, Zhang Jinku, Li Jinmei, Zhai Qiongli, Cheng Runfen, Wang Jiansong, Wang Haifeng, Yang Zhao
Format: Article
Language:English
Published: Sciendo 2023-06-01
Series:Acta Pharmaceutica
Subjects:
bladder cancer
medicarpin
cell cycle
arrest
apoptosis
therapy
Online Access:https://doi.org/10.2478/acph-2023-0016
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