Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature Review
Hydralazine, a commonly used arterial vasodilator for managing congestive heart failure and hypertension, is known to be associated with drug-induced lupus and, less frequently, antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Drug-induced AAV typically carries a favorable lon...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/cric/9932632 |
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| author | Ahmed Sami Hammami Osejie Oriaifo Sinda Hidri Sukhvir Singh Husam El Sharu Joshua Peltz Soroush Nomigolzar Kunjan Udani |
| author_facet | Ahmed Sami Hammami Osejie Oriaifo Sinda Hidri Sukhvir Singh Husam El Sharu Joshua Peltz Soroush Nomigolzar Kunjan Udani |
| author_sort | Ahmed Sami Hammami |
| collection | DOAJ |
| description | Hydralazine, a commonly used arterial vasodilator for managing congestive heart failure and hypertension, is known to be associated with drug-induced lupus and, less frequently, antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Drug-induced AAV typically carries a favorable long-term prognosis and is not commonly linked to cardiovascular or ocular involvement. Pericarditis cases associated with hydralazine have not been previously reported. We present a rare case involving an 85-year-old woman on long-term hydralazine therapy, initially presenting with acute lobar pneumonia. During her hospitalization, she developed pericarditis, chemosis, and conjunctivitis in her eyes, along with cutaneous lesions described as a maculopapular rash on her face, tender bullae on her digits, and a petechial rash on her back. Laboratory findings were consistent with drug-induced AAV, showing positive myeloperoxidase and proteinase 3 antibodies. An attempted diagnostic pericardiocentesis was unsuccessful. Hydralazine was discontinued, and she was successfully treated with corticosteroids and tolerated immunosuppression well. Subsequently, she recovered and was discharged from the hospital. |
| format | Article |
| id | doaj-art-5fe314cab72343de8f28514d8ff8e93b |
| institution | DOAJ |
| issn | 2090-6412 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-5fe314cab72343de8f28514d8ff8e93b2025-08-20T03:06:30ZengWileyCase Reports in Cardiology2090-64122025-01-01202510.1155/cric/9932632Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature ReviewAhmed Sami Hammami0Osejie Oriaifo1Sinda Hidri2Sukhvir Singh3Husam El Sharu4Joshua Peltz5Soroush Nomigolzar6Kunjan Udani7Department of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineDepartment of CardiologyDepartment of CardiologyHydralazine, a commonly used arterial vasodilator for managing congestive heart failure and hypertension, is known to be associated with drug-induced lupus and, less frequently, antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Drug-induced AAV typically carries a favorable long-term prognosis and is not commonly linked to cardiovascular or ocular involvement. Pericarditis cases associated with hydralazine have not been previously reported. We present a rare case involving an 85-year-old woman on long-term hydralazine therapy, initially presenting with acute lobar pneumonia. During her hospitalization, she developed pericarditis, chemosis, and conjunctivitis in her eyes, along with cutaneous lesions described as a maculopapular rash on her face, tender bullae on her digits, and a petechial rash on her back. Laboratory findings were consistent with drug-induced AAV, showing positive myeloperoxidase and proteinase 3 antibodies. An attempted diagnostic pericardiocentesis was unsuccessful. Hydralazine was discontinued, and she was successfully treated with corticosteroids and tolerated immunosuppression well. Subsequently, she recovered and was discharged from the hospital.http://dx.doi.org/10.1155/cric/9932632 |
| spellingShingle | Ahmed Sami Hammami Osejie Oriaifo Sinda Hidri Sukhvir Singh Husam El Sharu Joshua Peltz Soroush Nomigolzar Kunjan Udani Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature Review Case Reports in Cardiology |
| title | Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature Review |
| title_full | Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature Review |
| title_fullStr | Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature Review |
| title_full_unstemmed | Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature Review |
| title_short | Hydralazine-Induced ANCA Vasculitis Presenting With Pericarditis: A Novel Case and Literature Review |
| title_sort | hydralazine induced anca vasculitis presenting with pericarditis a novel case and literature review |
| url | http://dx.doi.org/10.1155/cric/9932632 |
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