The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin

The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin

<b>Background:</b> Elucidating the mechanisms underlying cisplatin-induced ototoxicity is critical for the clinical management of hearing loss. While cisplatin is known to penetrate the inner ear via the blood-labyrinth barrier in the stria vascularis, its precise damaging effects on mar...

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Bibliographic Details
Main Authors: Wenyang Lei, Wenting Yu, Ting Li, Wei Tang, Shimin Zong, Hongjun Xiao
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomedicines
Subjects:
cisplatin
stria vascularis
marginal cells
pyroptosis
GSDME
Online Access:https://www.mdpi.com/2227-9059/13/7/1680
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