Systemic sclerosis and the gastrointestinal tract
Systemic sclerosis (SSc) is an autoimmunological disease of unknown origin with complex pathogenesis and multiple organ involvement. It is characterised by vascular and immunological abnormalities leading to fibrosis of the skin and internal organs. It is a rather rare disease with a prevalence of a...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-09-01
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| Series: | Gastroenterology Review |
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| Online Access: | https://www.termedia.pl/Systemic-sclerosis-and-the-gastrointestinal-tract,41,30723,1,1.html |
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| _version_ | 1841548308639645696 |
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| author | Irena Walecka |
| author_facet | Irena Walecka |
| author_sort | Irena Walecka |
| collection | DOAJ |
| description | Systemic sclerosis (SSc) is an autoimmunological disease of unknown origin with complex pathogenesis and multiple organ involvement. It is characterised by vascular and immunological abnormalities leading to fibrosis of the skin and internal organs. It is a rather rare disease with a prevalence of around 20 per 100,000. The disease results in heterogeneous clinical findings and different courses. Systemic sclerosis usually begins with the onset of Raynaud’s phenomenon (RP), followed by skin sclerosis and internal organ involvement, although it may appear synchronously with RP. Gastrointestinal involvement is a serious and prevalent complication of SSc, and the oesophagus is the most frequently affected organ. Both limited and diffuse cutaneous SSc involve internal organs, with the involvement of the gastrointestinal tract as a leading cause of morbidity. At present, treatment is mainly symptomatic with no disease-modifying drugs. |
| format | Article |
| id | doaj-art-5fded2252d9c47ada20d405dd7f142f2 |
| institution | Kabale University |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-5fded2252d9c47ada20d405dd7f142f22025-01-10T14:06:17ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172017-09-0112316316810.5114/pg.2017.7046730723Systemic sclerosis and the gastrointestinal tractIrena WaleckaSystemic sclerosis (SSc) is an autoimmunological disease of unknown origin with complex pathogenesis and multiple organ involvement. It is characterised by vascular and immunological abnormalities leading to fibrosis of the skin and internal organs. It is a rather rare disease with a prevalence of around 20 per 100,000. The disease results in heterogeneous clinical findings and different courses. Systemic sclerosis usually begins with the onset of Raynaud’s phenomenon (RP), followed by skin sclerosis and internal organ involvement, although it may appear synchronously with RP. Gastrointestinal involvement is a serious and prevalent complication of SSc, and the oesophagus is the most frequently affected organ. Both limited and diffuse cutaneous SSc involve internal organs, with the involvement of the gastrointestinal tract as a leading cause of morbidity. At present, treatment is mainly symptomatic with no disease-modifying drugs.https://www.termedia.pl/Systemic-sclerosis-and-the-gastrointestinal-tract,41,30723,1,1.htmlsystemic sclerosis gastrointestinal involvement autoantibodies |
| spellingShingle | Irena Walecka Systemic sclerosis and the gastrointestinal tract Gastroenterology Review systemic sclerosis gastrointestinal involvement autoantibodies |
| title | Systemic sclerosis and the gastrointestinal tract |
| title_full | Systemic sclerosis and the gastrointestinal tract |
| title_fullStr | Systemic sclerosis and the gastrointestinal tract |
| title_full_unstemmed | Systemic sclerosis and the gastrointestinal tract |
| title_short | Systemic sclerosis and the gastrointestinal tract |
| title_sort | systemic sclerosis and the gastrointestinal tract |
| topic | systemic sclerosis gastrointestinal involvement autoantibodies |
| url | https://www.termedia.pl/Systemic-sclerosis-and-the-gastrointestinal-tract,41,30723,1,1.html |
| work_keys_str_mv | AT irenawalecka systemicsclerosisandthegastrointestinaltract |