Zinner’s syndrome in two young middle-aged men: a case report and review of the literature

Abstract Zinner syndrome (ZS) is a relatively uncommon congenital genitourinary malformation, characterised by a triad of conditions: unilateral renal hypoplasia or dysplasia, ipsilateral ejaculatory duct obstruction and seminal vesicle cysts. This association is caused by the hypoplasia of the dist...

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Main Authors: Yifan Huang, Bingzhi Han, Zikai Huang, Qianhao Huang, Tao Wang, Yuedong Chen
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Urology
Subjects:
Online Access:https://doi.org/10.1186/s12894-025-01806-7
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author Yifan Huang
Bingzhi Han
Zikai Huang
Qianhao Huang
Tao Wang
Yuedong Chen
author_facet Yifan Huang
Bingzhi Han
Zikai Huang
Qianhao Huang
Tao Wang
Yuedong Chen
author_sort Yifan Huang
collection DOAJ
description Abstract Zinner syndrome (ZS) is a relatively uncommon congenital genitourinary malformation, characterised by a triad of conditions: unilateral renal hypoplasia or dysplasia, ipsilateral ejaculatory duct obstruction and seminal vesicle cysts. This association is caused by the hypoplasia of the distal portion of the Wolffian duct between the 4th and 13th week of gestational age. To date, approximately 221 cases have been documented, the majority of which are case reports, with only a few being retrospective studies. However, the number of cases remains relatively limited. The lack of a clear and consistent set of symptoms can result in misdiagnosis. This paper presents two patients with two different presentations of Zinner syndrome. Clinical trial number: Not applicable.
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institution DOAJ
issn 1471-2490
language English
publishDate 2025-05-01
publisher BMC
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series BMC Urology
spelling doaj-art-5fde7ada137041959bd61f978dd1ddb72025-08-20T03:08:43ZengBMCBMC Urology1471-24902025-05-012511510.1186/s12894-025-01806-7Zinner’s syndrome in two young middle-aged men: a case report and review of the literatureYifan Huang0Bingzhi Han1Zikai Huang2Qianhao Huang3Tao Wang4Yuedong Chen5The School of Clinical Medicine, Fujian Medical UniversityThe Key Laboratory of Urinary Tract Tumours and Calculi, Department of Urology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityThe School of Clinical Medicine, Fujian Medical UniversityThe Key Laboratory of Urinary Tract Tumours and Calculi, Department of Urology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityThe Key Laboratory of Urinary Tract Tumours and Calculi, Department of Urology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityThe School of Clinical Medicine, Fujian Medical UniversityAbstract Zinner syndrome (ZS) is a relatively uncommon congenital genitourinary malformation, characterised by a triad of conditions: unilateral renal hypoplasia or dysplasia, ipsilateral ejaculatory duct obstruction and seminal vesicle cysts. This association is caused by the hypoplasia of the distal portion of the Wolffian duct between the 4th and 13th week of gestational age. To date, approximately 221 cases have been documented, the majority of which are case reports, with only a few being retrospective studies. However, the number of cases remains relatively limited. The lack of a clear and consistent set of symptoms can result in misdiagnosis. This paper presents two patients with two different presentations of Zinner syndrome. Clinical trial number: Not applicable.https://doi.org/10.1186/s12894-025-01806-7InfertilityGenitourinary anomaliesZinner syndromeRobotic surgery
spellingShingle Yifan Huang
Bingzhi Han
Zikai Huang
Qianhao Huang
Tao Wang
Yuedong Chen
Zinner’s syndrome in two young middle-aged men: a case report and review of the literature
BMC Urology
Infertility
Genitourinary anomalies
Zinner syndrome
Robotic surgery
title Zinner’s syndrome in two young middle-aged men: a case report and review of the literature
title_full Zinner’s syndrome in two young middle-aged men: a case report and review of the literature
title_fullStr Zinner’s syndrome in two young middle-aged men: a case report and review of the literature
title_full_unstemmed Zinner’s syndrome in two young middle-aged men: a case report and review of the literature
title_short Zinner’s syndrome in two young middle-aged men: a case report and review of the literature
title_sort zinner s syndrome in two young middle aged men a case report and review of the literature
topic Infertility
Genitourinary anomalies
Zinner syndrome
Robotic surgery
url https://doi.org/10.1186/s12894-025-01806-7
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AT qianhaohuang zinnerssyndromeintwoyoungmiddleagedmenacasereportandreviewoftheliterature
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