Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on Platelet Activating Factor and Eicosanoid Production By nasal Mucosa in Patients with A house Dust Mite Allergy
The relationship between the release of platelet activating factor (PAF), leukotriene C4/D4/EE (LTC4/D4/E4) and prostaglandin D2 (PGD2) from nasal mucosa in vivo was examined in 24 rhinitis patients allergic to the house dust mite (HDM). During a double blind placebo controlled cross-over study 200...
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| Format: | Article |
| Language: | English |
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Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000530 |
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| author | I. M. Garrelds T. de Graaf-in 't Veld A. P. H. Jansen R. Gerth van Wijk F. J. Zijlstra |
| author_facet | I. M. Garrelds T. de Graaf-in 't Veld A. P. H. Jansen R. Gerth van Wijk F. J. Zijlstra |
| author_sort | I. M. Garrelds |
| collection | DOAJ |
| description | The relationship between the release of platelet activating factor
(PAF), leukotriene C4/D4/EE
(LTC4/D4/E4) and prostaglandin D2 (PGD2)
from nasal mucosa in vivo was examined in 24 rhinitis patients
allergic to the house dust mite (HDM). During a double blind placebo
controlled cross-over study 200 μg fluticasone propionate aqueous
nasal spray (FPANS) was administered twice daily for two weeks. In
response to allergen provocation (100, 1 000, 10 000 Bu/ml) and
during the 9.5 h after this challenge the nasal fluid was obtained
by washing the nose with saline and the levels of PAF, LTC4/D4/E4 and
PGD2, as indicators of mediator release, were measured at the
following time-points: baseline (t = − 1/2), allergen provocation with
10 000 Bu/ml (t = 0), 3.5 and 7.5 h (late phase). After allergen
provocation the levels of the mediators increased in the nasal
fluids of placebo treated patients (x-fold increase to baseline:
PAF, 15; LTC4/D4/E4, 12; PGD2, 1.5). In fluids of patients treated
with FPANS these levels tended to decrease. At the time of
provocation the levels of PAF, LTC4/D4/E4 and PGD2 showed a significant
correlation. The results indicate that these mediators can be used
as markers of allergic reactions against house dust mites and that
fluticasone propionate aqueous nasal spray tended to reduce the
release of mediators of inflammation correlated with beneficial
effects on clinical symptoms in this type of allergic reactions. |
| format | Article |
| id | doaj-art-5fde3843235343a8a2eb6892b3ebe32f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5fde3843235343a8a2eb6892b3ebe32f2025-08-20T03:34:53ZengWileyMediators of Inflammation0962-93511466-18611994-01-013538138510.1155/S0962935194000530Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on Platelet Activating Factor and Eicosanoid Production By nasal Mucosa in Patients with A house Dust Mite AllergyI. M. Garrelds0T. de Graaf-in 't Veld1A. P. H. Jansen2R. Gerth van Wijk3F. J. Zijlstra4Department of Pharmacology, Faculty of Medicine, Erasmus University Rotterdam, The NetherlandsDepartment of Allergology, University Hospital Rotterdam-Dijkzigt, P.O. Box 1738, Rotterdam 3000 DR, The NetherlandsDepartment of Allergology, University Hospital Rotterdam-Dijkzigt, P.O. Box 1738, Rotterdam 3000 DR, The NetherlandsDepartment of Allergology, University Hospital Rotterdam-Dijkzigt, P.O. Box 1738, Rotterdam 3000 DR, The NetherlandsDepartment of Pharmacology, Faculty of Medicine, Erasmus University Rotterdam, The NetherlandsThe relationship between the release of platelet activating factor (PAF), leukotriene C4/D4/EE (LTC4/D4/E4) and prostaglandin D2 (PGD2) from nasal mucosa in vivo was examined in 24 rhinitis patients allergic to the house dust mite (HDM). During a double blind placebo controlled cross-over study 200 μg fluticasone propionate aqueous nasal spray (FPANS) was administered twice daily for two weeks. In response to allergen provocation (100, 1 000, 10 000 Bu/ml) and during the 9.5 h after this challenge the nasal fluid was obtained by washing the nose with saline and the levels of PAF, LTC4/D4/E4 and PGD2, as indicators of mediator release, were measured at the following time-points: baseline (t = − 1/2), allergen provocation with 10 000 Bu/ml (t = 0), 3.5 and 7.5 h (late phase). After allergen provocation the levels of the mediators increased in the nasal fluids of placebo treated patients (x-fold increase to baseline: PAF, 15; LTC4/D4/E4, 12; PGD2, 1.5). In fluids of patients treated with FPANS these levels tended to decrease. At the time of provocation the levels of PAF, LTC4/D4/E4 and PGD2 showed a significant correlation. The results indicate that these mediators can be used as markers of allergic reactions against house dust mites and that fluticasone propionate aqueous nasal spray tended to reduce the release of mediators of inflammation correlated with beneficial effects on clinical symptoms in this type of allergic reactions.http://dx.doi.org/10.1155/S0962935194000530 |
| spellingShingle | I. M. Garrelds T. de Graaf-in 't Veld A. P. H. Jansen R. Gerth van Wijk F. J. Zijlstra Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on Platelet Activating Factor and Eicosanoid Production By nasal Mucosa in Patients with A house Dust Mite Allergy Mediators of Inflammation |
| title | Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on
Platelet Activating Factor and Eicosanoid Production By nasal Mucosa
in Patients with A house Dust Mite Allergy |
| title_full | Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on
Platelet Activating Factor and Eicosanoid Production By nasal Mucosa
in Patients with A house Dust Mite Allergy |
| title_fullStr | Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on
Platelet Activating Factor and Eicosanoid Production By nasal Mucosa
in Patients with A house Dust Mite Allergy |
| title_full_unstemmed | Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on
Platelet Activating Factor and Eicosanoid Production By nasal Mucosa
in Patients with A house Dust Mite Allergy |
| title_short | Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on
Platelet Activating Factor and Eicosanoid Production By nasal Mucosa
in Patients with A house Dust Mite Allergy |
| title_sort | effect of fluticasone propionate aqueous nasal spray treatment on platelet activating factor and eicosanoid production by nasal mucosa in patients with a house dust mite allergy |
| url | http://dx.doi.org/10.1155/S0962935194000530 |
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