Model-free photon analysis of diffusion-based single-molecule FRET experiments

Model-free photon analysis of diffusion-based single-molecule FRET experiments

Abstract Photon-by-photon analysis tools for diffusion-based single-molecule Förster resonance energy transfer (smFRET) experiments often describe protein dynamics with Markov models. However, FRET efficiencies are only projections of the conformational space such that the measured dynamics can appe...

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Bibliographic Details
Main Authors: Ivan Terterov, Daniel Nettels, Tanya Lastiza-Male, Kim Bartels, Christian Löw, Renee Vancraenenbroeck, Itay Carmel, Gabriel Rosenblum, Hagen Hofmann
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60764-8
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