Cold induced pseudoneutropenia in human immunodeficiency virus infection: first case report and review of related articles
Cold agglutination of erythrocyte or platelet aggregation in vitro due to cold agglutination are well recognized and extensively studied. Aggregation of leucocyte is a rare hematological phenomenon resulting in a spurious low leucocyte count performed using automated hematology analyzers. Aggregatio...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1869 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850215627436851200 |
|---|---|
| author | Prashant Goyal Dipti Agrawal Jitender Kailash Sompal Singh |
| author_facet | Prashant Goyal Dipti Agrawal Jitender Kailash Sompal Singh |
| author_sort | Prashant Goyal |
| collection | DOAJ |
| description | Cold agglutination of erythrocyte or platelet aggregation in vitro due to cold agglutination are well recognized and extensively studied. Aggregation of leucocyte is a rare hematological phenomenon resulting in a spurious low leucocyte count performed using automated hematology analyzers. Aggregation of leucocyte may relate to malignancy, lymphoproliferative disorders, infection, liver diseases, or autoimmune disorders. It is believed that the mechanism of leucocyte aggregation is mainly related to the use of EDTA (ethylene diamine tetraacetic acid) anticoagulant or is temperature-mediated. Leucoagglutination is associated with either a spurious leucopenia or an underestimation of leucocytosis. This can adversely affect management decisions in terms of unnecessary management of leucopenia or ignoring a leucocytosis that may be indicator of an underlying serious disease. To our knowledge, we report here for the first time the occurrence of pseudoneutropenia due to temperature-mediated, EDTA-independent neutrophil agglutination in adult with human immunodeficiency virus (HIV) infection. |
| format | Article |
| id | doaj-art-5fd6bd3237c845c69ec8b33a73318c20 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-5fd6bd3237c845c69ec8b33a73318c202025-08-20T02:08:34ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011Cold induced pseudoneutropenia in human immunodeficiency virus infection: first case report and review of related articlesPrashant Goyal0Dipti Agrawal1Jitender Kailash2Sompal Singh3Swami Dayanand Hospital, Dilshad Garden, Delhi, IndiaBatra Hospital and Medical Research Centre, Tughlakabad Institutional Area, New DelhiKailash ClinicSwami Dayanand Hospital, Dilshad Garden, DelhiCold agglutination of erythrocyte or platelet aggregation in vitro due to cold agglutination are well recognized and extensively studied. Aggregation of leucocyte is a rare hematological phenomenon resulting in a spurious low leucocyte count performed using automated hematology analyzers. Aggregation of leucocyte may relate to malignancy, lymphoproliferative disorders, infection, liver diseases, or autoimmune disorders. It is believed that the mechanism of leucocyte aggregation is mainly related to the use of EDTA (ethylene diamine tetraacetic acid) anticoagulant or is temperature-mediated. Leucoagglutination is associated with either a spurious leucopenia or an underestimation of leucocytosis. This can adversely affect management decisions in terms of unnecessary management of leucopenia or ignoring a leucocytosis that may be indicator of an underlying serious disease. To our knowledge, we report here for the first time the occurrence of pseudoneutropenia due to temperature-mediated, EDTA-independent neutrophil agglutination in adult with human immunodeficiency virus (HIV) infection.https://mjhid.org/index.php/mjhid/article/view/1869PseudoneutropeniaNeutrophil aggregationCold agglutinationHIVEDTA |
| spellingShingle | Prashant Goyal Dipti Agrawal Jitender Kailash Sompal Singh Cold induced pseudoneutropenia in human immunodeficiency virus infection: first case report and review of related articles Mediterranean Journal of Hematology and Infectious Diseases Pseudoneutropenia Neutrophil aggregation Cold agglutination HIV EDTA |
| title | Cold induced pseudoneutropenia in human immunodeficiency virus infection: first case report and review of related articles |
| title_full | Cold induced pseudoneutropenia in human immunodeficiency virus infection: first case report and review of related articles |
| title_fullStr | Cold induced pseudoneutropenia in human immunodeficiency virus infection: first case report and review of related articles |
| title_full_unstemmed | Cold induced pseudoneutropenia in human immunodeficiency virus infection: first case report and review of related articles |
| title_short | Cold induced pseudoneutropenia in human immunodeficiency virus infection: first case report and review of related articles |
| title_sort | cold induced pseudoneutropenia in human immunodeficiency virus infection first case report and review of related articles |
| topic | Pseudoneutropenia Neutrophil aggregation Cold agglutination HIV EDTA |
| url | https://mjhid.org/index.php/mjhid/article/view/1869 |
| work_keys_str_mv | AT prashantgoyal coldinducedpseudoneutropeniainhumanimmunodeficiencyvirusinfectionfirstcasereportandreviewofrelatedarticles AT diptiagrawal coldinducedpseudoneutropeniainhumanimmunodeficiencyvirusinfectionfirstcasereportandreviewofrelatedarticles AT jitenderkailash coldinducedpseudoneutropeniainhumanimmunodeficiencyvirusinfectionfirstcasereportandreviewofrelatedarticles AT sompalsingh coldinducedpseudoneutropeniainhumanimmunodeficiencyvirusinfectionfirstcasereportandreviewofrelatedarticles |