Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 years
Aim. To study arterial structure and function in patients aged over 60 years with Stage I-II isolated systolic and systolo-diastolic arterial hypertension (ISAH, SDAH). To assess vasoprotective effects of 24-week treatment with a calcium antagonist nifedipine (Cordaflex® RD).Material and methods. Th...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2008-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1724 |
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| author | V. E. Oleynikov I. B. Matrosova E. E. Grishaeva N. A. Borisova E. I. Yastrebova |
| author_facet | V. E. Oleynikov I. B. Matrosova E. E. Grishaeva N. A. Borisova E. I. Yastrebova |
| author_sort | V. E. Oleynikov |
| collection | DOAJ |
| description | Aim. To study arterial structure and function in patients aged over 60 years with Stage I-II isolated systolic and systolo-diastolic arterial hypertension (ISAH, SDAH). To assess vasoprotective effects of 24-week treatment with a calcium antagonist nifedipine (Cordaflex® RD).Material and methods. This prospective 24-week study included 48 patients with Stage I-II AH, aged over 60 years. SDAH and ISAH patients were administered Cordaflex® RD (40 mg/d), and treatment effectiveness was assessed by office blood pressure (BP) dynamics. Vasoprotective effects of the medication were assessed by volume sphyg-mography and echocardiography dynamics.Results. Cordaflex® RD demonstrated not only good antihypertensive effects, but also improved arterial elasticity, reducing pulse wave velocity (PWV) in various vessel types. In ISAH patients, its effects were maximal for elastic type vessels, and in SDAH individuals - for muscular type vessels. The medication reduced intima-media thickness (IMT) increase and improved endothelial function.Conclusion. In ISAH and SDAH patients aged over 60 years, Cordaflex® RD improved endothelial function and arterial wall elasticity, providing vasoprotection and target BP level achievement |
| format | Article |
| id | doaj-art-5fd5ec574bae4e71a9f3da512dc364cb |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2008-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-5fd5ec574bae4e71a9f3da512dc364cb2025-08-20T03:57:09Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252008-12-017827321442Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 yearsV. E. Oleynikov0I. B. Matrosova1E. E. Grishaeva2N. A. Borisova3E. I. Yastrebova4Medical Institute, Penza State University. PenzaMedical Institute, Penza State University. PenzaMedical Institute, Penza State University. PenzaMedical Institute, Penza State University. PenzaMedical Institute, Penza State University. PenzaAim. To study arterial structure and function in patients aged over 60 years with Stage I-II isolated systolic and systolo-diastolic arterial hypertension (ISAH, SDAH). To assess vasoprotective effects of 24-week treatment with a calcium antagonist nifedipine (Cordaflex® RD).Material and methods. This prospective 24-week study included 48 patients with Stage I-II AH, aged over 60 years. SDAH and ISAH patients were administered Cordaflex® RD (40 mg/d), and treatment effectiveness was assessed by office blood pressure (BP) dynamics. Vasoprotective effects of the medication were assessed by volume sphyg-mography and echocardiography dynamics.Results. Cordaflex® RD demonstrated not only good antihypertensive effects, but also improved arterial elasticity, reducing pulse wave velocity (PWV) in various vessel types. In ISAH patients, its effects were maximal for elastic type vessels, and in SDAH individuals - for muscular type vessels. The medication reduced intima-media thickness (IMT) increase and improved endothelial function.Conclusion. In ISAH and SDAH patients aged over 60 years, Cordaflex® RD improved endothelial function and arterial wall elasticity, providing vasoprotection and target BP level achievementhttps://cardiovascular.elpub.ru/jour/article/view/1724nifedipineisolated systolic and systolo-diastolic arterial hypertensionarterial stiffnessendothelial dysfunctionpulse wave velocity |
| spellingShingle | V. E. Oleynikov I. B. Matrosova E. E. Grishaeva N. A. Borisova E. I. Yastrebova Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 years Кардиоваскулярная терапия и профилактика nifedipine isolated systolic and systolo-diastolic arterial hypertension arterial stiffness endothelial dysfunction pulse wave velocity |
| title | Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 years |
| title_full | Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 years |
| title_fullStr | Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 years |
| title_full_unstemmed | Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 years |
| title_short | Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 years |
| title_sort | long term nifedipine cr therapy and arterial characteristics in hypertensive patients aged over 60 years |
| topic | nifedipine isolated systolic and systolo-diastolic arterial hypertension arterial stiffness endothelial dysfunction pulse wave velocity |
| url | https://cardiovascular.elpub.ru/jour/article/view/1724 |
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