Platelet Membrane-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Sildenafil for Targeted Therapy of Vein Graft Intimal Hyperplasia

Platelet Membrane-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Sildenafil for Targeted Therapy of Vein Graft Intimal Hyperplasia

Autologous vein grafts have attracted widespread attention for their high transplantation success rate and low risk of immune rejection. However, this technique is limited by the postoperative neointimal hyperplasia, recurrent stenosis and vein graft occlusion. Hence, we propose the platelet membran...

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Bibliographic Details
Main Authors: Fajing Yang, Yihui Qiu, Xueting Xie, Xingjian Zhou, Shunfu Wang, Jialu Weng, Lina Wu, Yizhe Ma, Ziyue Wang, Wenzhang Jin, Bicheng Chen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Platelet membrane
Sildenafil
PLGA
Vein graft
Intimal hyperplasia
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156724000501
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