Protein-specific immune response elicited by the Shigella sonnei 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to Shigella

Protein-specific immune response elicited by the Shigella sonnei 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to Shigella

ABSTRACT Shigella is a leading cause of diarrheal morbidity and mortality in young children from low- and middle-income countries. Here, we aimed to verify the ability of the generalized modules for membrane antigens (GMMA)-based Shigella sonnei candidate vaccine 1790GAHB to elicit an anti-protein a...

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Main Authors: Arlo Z. Randall, Valentino Conti, Usman Nakakana, Xiaowu Liang, Andy A. Teng, Antonio Lorenzo Di Pasquale, Melissa Kapulu, Robert Frenck, Odile Launay, Pietro Ferruzzi, Antonella Silvia Sciré, Elisa Marchetti, Christina Obiero, Jozelyn V. Pablo, Joshua Edgar, Philip Bejon, Adam D. Shandling, Joseph J. Campo, Angela Yee, Laura B. Martin, Audino Podda, Francesca Micoli
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSphere
Subjects:
protein microarray
proteome immune profiling
Shigella
vaccine
Generalized Modules for Membrane Antigens (GMMA)
Online Access:https://journals.asm.org/doi/10.1128/msphere.01057-24
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