Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis
Brucella is an intracellular infection bacterium; the pathogenesis of Brucella and chronicity of infection may be related to the immune response of T cells. T lymphocytes mainly participate in cellular immune response. The extent of different T cell subsets imbalanced and their function dysregulated...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/3783209 |
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| author | Rongjiong Zheng Songsong Xie Qiong Zhang Ling Cao Shaniya Niyazi Xiaobo Lu Lihua Sun Yan Zhou Yuexin Zhang Kai Wang |
| author_facet | Rongjiong Zheng Songsong Xie Qiong Zhang Ling Cao Shaniya Niyazi Xiaobo Lu Lihua Sun Yan Zhou Yuexin Zhang Kai Wang |
| author_sort | Rongjiong Zheng |
| collection | DOAJ |
| description | Brucella is an intracellular infection bacterium; the pathogenesis of Brucella and chronicity of infection may be related to the immune response of T cells. T lymphocytes mainly participate in cellular immune response. The extent of different T cell subsets imbalanced and their function dysregulated in patients with brucellosis remain not explicit. We grouped patients at different stages (acute, chronic, and convalescent). The frequencies of Th1, Th2, Th17, Treg, and PD-1 (programmed cell death protein 1) in peripheral blood were examined by flow cytometry, and the expressions of T lymphocyte cytokines in serum were detected by cytometric bead array. Th1, Th17, and Treg cell immunity was predominant in the acute stage, while Th2, Th17, and Treg cell immunity was predominant in the chronic stage. The expressions of PD-1 on CD4+ and CD8+ T lymphocytes were significantly different in acute and chronic patients. The percentages of Th1 cells in convalescent patients were still higher than those in healthy controls within one year after withdrawal. The expression of T lymphocyte cytokines in serum was different in patients at different stages. These results indicate that peripheral T lymphocyte immunity was involved in patients with brucellosis and represents a target for the preclinical and clinical assessment of novel immunomodulating therapeutics. The patients’ immune function had not completely recovered in a short period of time during convalescence, so long-term follow-up of convalescent patients is needed. |
| format | Article |
| id | doaj-art-5fd160e4ba204f31b074c12d6ec13f42 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5fd160e4ba204f31b074c12d6ec13f422025-02-03T05:51:57ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/37832093783209Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with BrucellosisRongjiong Zheng0Songsong Xie1Qiong Zhang2Ling Cao3Shaniya Niyazi4Xiaobo Lu5Lihua Sun6Yan Zhou7Yuexin Zhang8Kai Wang9Department of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, ChinaDepartment of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, Xinjiang 830011, ChinaBrucella is an intracellular infection bacterium; the pathogenesis of Brucella and chronicity of infection may be related to the immune response of T cells. T lymphocytes mainly participate in cellular immune response. The extent of different T cell subsets imbalanced and their function dysregulated in patients with brucellosis remain not explicit. We grouped patients at different stages (acute, chronic, and convalescent). The frequencies of Th1, Th2, Th17, Treg, and PD-1 (programmed cell death protein 1) in peripheral blood were examined by flow cytometry, and the expressions of T lymphocyte cytokines in serum were detected by cytometric bead array. Th1, Th17, and Treg cell immunity was predominant in the acute stage, while Th2, Th17, and Treg cell immunity was predominant in the chronic stage. The expressions of PD-1 on CD4+ and CD8+ T lymphocytes were significantly different in acute and chronic patients. The percentages of Th1 cells in convalescent patients were still higher than those in healthy controls within one year after withdrawal. The expression of T lymphocyte cytokines in serum was different in patients at different stages. These results indicate that peripheral T lymphocyte immunity was involved in patients with brucellosis and represents a target for the preclinical and clinical assessment of novel immunomodulating therapeutics. The patients’ immune function had not completely recovered in a short period of time during convalescence, so long-term follow-up of convalescent patients is needed.http://dx.doi.org/10.1155/2019/3783209 |
| spellingShingle | Rongjiong Zheng Songsong Xie Qiong Zhang Ling Cao Shaniya Niyazi Xiaobo Lu Lihua Sun Yan Zhou Yuexin Zhang Kai Wang Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis Journal of Immunology Research |
| title | Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis |
| title_full | Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis |
| title_fullStr | Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis |
| title_full_unstemmed | Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis |
| title_short | Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis |
| title_sort | circulating th1 th2 th17 treg and pd 1 levels in patients with brucellosis |
| url | http://dx.doi.org/10.1155/2019/3783209 |
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