The past, present, future of Listeria monocytogenes: Understanding the molecular pathways, antibiotic resistance and public health implications
Antibiotic resistance is a grave, potential threat to global health due to the continuing difficulty in treating bacterial infections. Misuse and overuse of antibiotics in humans and animals increase this resistance by creating ''superbugs'' impervious to multiple drug therapies....
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Elsevier
2025-09-01
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| Series: | Medicine in Microecology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097825000084 |
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| author | Arpita Anupama Veilumuthu Pattapulavar John Godwin Christopher |
| author_facet | Arpita Anupama Veilumuthu Pattapulavar John Godwin Christopher |
| author_sort | Arpita Anupama |
| collection | DOAJ |
| description | Antibiotic resistance is a grave, potential threat to global health due to the continuing difficulty in treating bacterial infections. Misuse and overuse of antibiotics in humans and animals increase this resistance by creating ''superbugs'' impervious to multiple drug therapies. One pathogen that is acquiring resistance is Listeria monocytogenes, a gram-positive bacterium responsible for listeriosis, mainly in immunocompromised individuals. This pathogen's potential for biofilm formation in food processing environments enhances the threat even more, since such biofilms protect the bacteria from standard cleaning procedures and enhance its resistance to antibiotics. Listeria monocytogenes has several mechanisms of resistance against antibiotics by genetic alternations, efflux pumps, and biofilm formation, which exclude the antibiotic, and enzymatic degradation. These mechanisms make the bacteria successful in surviving a hostile environment and resisting several classes of antibiotics; hence, listeriosis is increasingly difficult to treat. It is, therefore, very important to understand the molecular dynamics of Listeria monocytogenes and its strategies of resistance if the design of new therapeutic approaches is to be successful and public health measures are to be effective in controlling the spread of the pathogen. Precisely, this paper attempts a detailed review of the mechanisms of Listeria monocytogenes pathogenesis and antibiotic resistance, together with public health implications that call for urgent innovative strategies in the war against this resilient pathogen. |
| format | Article |
| id | doaj-art-5fd05218df6e4a92baf67b6d1cc782db |
| institution | Kabale University |
| issn | 2590-0978 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Microecology |
| spelling | doaj-art-5fd05218df6e4a92baf67b6d1cc782db2025-08-20T04:03:25ZengElsevierMedicine in Microecology2590-09782025-09-012510012710.1016/j.medmic.2025.100127The past, present, future of Listeria monocytogenes: Understanding the molecular pathways, antibiotic resistance and public health implicationsArpita Anupama0Veilumuthu Pattapulavar1John Godwin Christopher2Department of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, IndiaDepartment of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, IndiaCorresponding author.; Department of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, IndiaAntibiotic resistance is a grave, potential threat to global health due to the continuing difficulty in treating bacterial infections. Misuse and overuse of antibiotics in humans and animals increase this resistance by creating ''superbugs'' impervious to multiple drug therapies. One pathogen that is acquiring resistance is Listeria monocytogenes, a gram-positive bacterium responsible for listeriosis, mainly in immunocompromised individuals. This pathogen's potential for biofilm formation in food processing environments enhances the threat even more, since such biofilms protect the bacteria from standard cleaning procedures and enhance its resistance to antibiotics. Listeria monocytogenes has several mechanisms of resistance against antibiotics by genetic alternations, efflux pumps, and biofilm formation, which exclude the antibiotic, and enzymatic degradation. These mechanisms make the bacteria successful in surviving a hostile environment and resisting several classes of antibiotics; hence, listeriosis is increasingly difficult to treat. It is, therefore, very important to understand the molecular dynamics of Listeria monocytogenes and its strategies of resistance if the design of new therapeutic approaches is to be successful and public health measures are to be effective in controlling the spread of the pathogen. Precisely, this paper attempts a detailed review of the mechanisms of Listeria monocytogenes pathogenesis and antibiotic resistance, together with public health implications that call for urgent innovative strategies in the war against this resilient pathogen.http://www.sciencedirect.com/science/article/pii/S2590097825000084Listeria monocytogenesFood borne pathogenAntibiotic resistanceGenetic modificationsResistance mechanismsEnzymatic degradation |
| spellingShingle | Arpita Anupama Veilumuthu Pattapulavar John Godwin Christopher The past, present, future of Listeria monocytogenes: Understanding the molecular pathways, antibiotic resistance and public health implications Medicine in Microecology Listeria monocytogenes Food borne pathogen Antibiotic resistance Genetic modifications Resistance mechanisms Enzymatic degradation |
| title | The past, present, future of Listeria monocytogenes: Understanding the molecular pathways, antibiotic resistance and public health implications |
| title_full | The past, present, future of Listeria monocytogenes: Understanding the molecular pathways, antibiotic resistance and public health implications |
| title_fullStr | The past, present, future of Listeria monocytogenes: Understanding the molecular pathways, antibiotic resistance and public health implications |
| title_full_unstemmed | The past, present, future of Listeria monocytogenes: Understanding the molecular pathways, antibiotic resistance and public health implications |
| title_short | The past, present, future of Listeria monocytogenes: Understanding the molecular pathways, antibiotic resistance and public health implications |
| title_sort | past present future of listeria monocytogenes understanding the molecular pathways antibiotic resistance and public health implications |
| topic | Listeria monocytogenes Food borne pathogen Antibiotic resistance Genetic modifications Resistance mechanisms Enzymatic degradation |
| url | http://www.sciencedirect.com/science/article/pii/S2590097825000084 |
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