Transcriptional signatures of secondary hair follicles during annual cashmere growth
Abstract Cashmere grows from the secondary hair follicles (SHFs) that synchronously regenerate and degenerate in a circannual rhythm. Most studies examining factors related to cashmere growth have been performed on goat skin. However, the molecular properties and regulators preferentially expressed...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-024-04316-7 |
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| author | Yanlei Liu Minglin Wang Zehao Liu Xinyue Liang Shengda Sheng Han Dai Junpeng Zhang Shuyi Zhang Xinghui Zhang Huiling Xue |
| author_facet | Yanlei Liu Minglin Wang Zehao Liu Xinyue Liang Shengda Sheng Han Dai Junpeng Zhang Shuyi Zhang Xinghui Zhang Huiling Xue |
| author_sort | Yanlei Liu |
| collection | DOAJ |
| description | Abstract Cashmere grows from the secondary hair follicles (SHFs) that synchronously regenerate and degenerate in a circannual rhythm. Most studies examining factors related to cashmere growth have been performed on goat skin. However, the molecular properties and regulators preferentially expressed in SHFs are less clear. In this study, we isolated the SHFs from skin under a dissecting microscope and analysed the molecular signatures across the annual growth. It demonstrated the transcriptional profile of the isolated SHFs could accurately decipher the growth state and unequivocally distinguish three phases of the cashmere growth. We identified 1,289 molecular signatures that were differentially expressed between different phases. Real-time PCR verified the accuracy and reliability of our sequencing data for the representative genes. Taken together, the transcriptional profiles and identified molecular signatures extended previous findings, and provided a variety of promising targets for cashmere production, thereby offering valuable starting points for future work. |
| format | Article |
| id | doaj-art-5fce2a37b98e498ea1a5ae4c5e9fc815 |
| institution | DOAJ |
| issn | 2052-4463 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-5fce2a37b98e498ea1a5ae4c5e9fc8152025-08-20T02:57:39ZengNature PortfolioScientific Data2052-44632024-12-011111510.1038/s41597-024-04316-7Transcriptional signatures of secondary hair follicles during annual cashmere growthYanlei Liu0Minglin Wang1Zehao Liu2Xinyue Liang3Shengda Sheng4Han Dai5Junpeng Zhang6Shuyi Zhang7Xinghui Zhang8Huiling Xue9College of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)College of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)College of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)College of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)College of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)College of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)College of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)College of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)Modern Agricultural Production Base Construction Engineering Centre of Liaoning ProvinceCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University (SYAU)Abstract Cashmere grows from the secondary hair follicles (SHFs) that synchronously regenerate and degenerate in a circannual rhythm. Most studies examining factors related to cashmere growth have been performed on goat skin. However, the molecular properties and regulators preferentially expressed in SHFs are less clear. In this study, we isolated the SHFs from skin under a dissecting microscope and analysed the molecular signatures across the annual growth. It demonstrated the transcriptional profile of the isolated SHFs could accurately decipher the growth state and unequivocally distinguish three phases of the cashmere growth. We identified 1,289 molecular signatures that were differentially expressed between different phases. Real-time PCR verified the accuracy and reliability of our sequencing data for the representative genes. Taken together, the transcriptional profiles and identified molecular signatures extended previous findings, and provided a variety of promising targets for cashmere production, thereby offering valuable starting points for future work.https://doi.org/10.1038/s41597-024-04316-7 |
| spellingShingle | Yanlei Liu Minglin Wang Zehao Liu Xinyue Liang Shengda Sheng Han Dai Junpeng Zhang Shuyi Zhang Xinghui Zhang Huiling Xue Transcriptional signatures of secondary hair follicles during annual cashmere growth Scientific Data |
| title | Transcriptional signatures of secondary hair follicles during annual cashmere growth |
| title_full | Transcriptional signatures of secondary hair follicles during annual cashmere growth |
| title_fullStr | Transcriptional signatures of secondary hair follicles during annual cashmere growth |
| title_full_unstemmed | Transcriptional signatures of secondary hair follicles during annual cashmere growth |
| title_short | Transcriptional signatures of secondary hair follicles during annual cashmere growth |
| title_sort | transcriptional signatures of secondary hair follicles during annual cashmere growth |
| url | https://doi.org/10.1038/s41597-024-04316-7 |
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