Graphene Field‐Effect Transistors toward Study of Cardiac Ischemia at Early Stage
Abstract Ischemia and reperfusion states are studied in a network of cardiomyocytes as a part of real‐state conditions of heart injuries and inflammations, specifically myocardial infractions. Arrays of graphene field‐effect transistors (GFETs) fabricated in this work are used for extracellular reco...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-02-01
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| Series: | Advanced Electronic Materials |
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| Online Access: | https://doi.org/10.1002/aelm.202400332 |
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| author | Hanna Hlukhova Dmitry Kireev Andreas Offenhäusser Denys Pustovyi Svetlana Vitusevich |
| author_facet | Hanna Hlukhova Dmitry Kireev Andreas Offenhäusser Denys Pustovyi Svetlana Vitusevich |
| author_sort | Hanna Hlukhova |
| collection | DOAJ |
| description | Abstract Ischemia and reperfusion states are studied in a network of cardiomyocytes as a part of real‐state conditions of heart injuries and inflammations, specifically myocardial infractions. Arrays of graphene field‐effect transistors (GFETs) fabricated in this work are used for extracellular recordings of ischemia states of cardiac cells during the external triggering of the ischemia infarction. The low‐concentrated ischemic buffer solution allows to create a cell‐stress condition resulting in the reperfusion process. The results show that the action potentials recorded with the graphene transistors, especially their shape, and duration of the active segment in measured extracellular action potentials, can be used to characterize the real state of the studied cardiac cell culture. The unique property of GFETs to detect such small changes in the action potential of cells in cardiac healthy and unhealthy states provides prospects for building the next generation of ultrasensitive biosensors, enabling the detection of acute ischemic states at an early stage. |
| format | Article |
| id | doaj-art-5fcb5737d4d64f8da9672877914b3d16 |
| institution | DOAJ |
| issn | 2199-160X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Electronic Materials |
| spelling | doaj-art-5fcb5737d4d64f8da9672877914b3d162025-08-20T03:12:20ZengWiley-VCHAdvanced Electronic Materials2199-160X2025-02-01112n/an/a10.1002/aelm.202400332Graphene Field‐Effect Transistors toward Study of Cardiac Ischemia at Early StageHanna Hlukhova0Dmitry Kireev1Andreas Offenhäusser2Denys Pustovyi3Svetlana Vitusevich4Institute of Biological Information Processing (IBI‐3) Forschungszentrum Jülich 52428 Jülich GermanyInstitute of Biological Information Processing (IBI‐3) Forschungszentrum Jülich 52428 Jülich GermanyInstitute of Biological Information Processing (IBI‐3) Forschungszentrum Jülich 52428 Jülich GermanyInstitute of Biological Information Processing (IBI‐3) Forschungszentrum Jülich 52428 Jülich GermanyInstitute of Biological Information Processing (IBI‐3) Forschungszentrum Jülich 52428 Jülich GermanyAbstract Ischemia and reperfusion states are studied in a network of cardiomyocytes as a part of real‐state conditions of heart injuries and inflammations, specifically myocardial infractions. Arrays of graphene field‐effect transistors (GFETs) fabricated in this work are used for extracellular recordings of ischemia states of cardiac cells during the external triggering of the ischemia infarction. The low‐concentrated ischemic buffer solution allows to create a cell‐stress condition resulting in the reperfusion process. The results show that the action potentials recorded with the graphene transistors, especially their shape, and duration of the active segment in measured extracellular action potentials, can be used to characterize the real state of the studied cardiac cell culture. The unique property of GFETs to detect such small changes in the action potential of cells in cardiac healthy and unhealthy states provides prospects for building the next generation of ultrasensitive biosensors, enabling the detection of acute ischemic states at an early stage.https://doi.org/10.1002/aelm.202400332biosensorscardiomyocytesgraphene FETsischemiananotechnology |
| spellingShingle | Hanna Hlukhova Dmitry Kireev Andreas Offenhäusser Denys Pustovyi Svetlana Vitusevich Graphene Field‐Effect Transistors toward Study of Cardiac Ischemia at Early Stage Advanced Electronic Materials biosensors cardiomyocytes graphene FETs ischemia nanotechnology |
| title | Graphene Field‐Effect Transistors toward Study of Cardiac Ischemia at Early Stage |
| title_full | Graphene Field‐Effect Transistors toward Study of Cardiac Ischemia at Early Stage |
| title_fullStr | Graphene Field‐Effect Transistors toward Study of Cardiac Ischemia at Early Stage |
| title_full_unstemmed | Graphene Field‐Effect Transistors toward Study of Cardiac Ischemia at Early Stage |
| title_short | Graphene Field‐Effect Transistors toward Study of Cardiac Ischemia at Early Stage |
| title_sort | graphene field effect transistors toward study of cardiac ischemia at early stage |
| topic | biosensors cardiomyocytes graphene FETs ischemia nanotechnology |
| url | https://doi.org/10.1002/aelm.202400332 |
| work_keys_str_mv | AT hannahlukhova graphenefieldeffecttransistorstowardstudyofcardiacischemiaatearlystage AT dmitrykireev graphenefieldeffecttransistorstowardstudyofcardiacischemiaatearlystage AT andreasoffenhausser graphenefieldeffecttransistorstowardstudyofcardiacischemiaatearlystage AT denyspustovyi graphenefieldeffecttransistorstowardstudyofcardiacischemiaatearlystage AT svetlanavitusevich graphenefieldeffecttransistorstowardstudyofcardiacischemiaatearlystage |