Association of α-SMA/FAP-positive cancer-associated fibroblasts with clinicopathological features and prognosis in extrahepatic cholangiocarcinoma

Association of α-SMA/FAP-positive cancer-associated fibroblasts with clinicopathological features and prognosis in extrahepatic cholangiocarcinoma

Abstract Objective This study aimed to evaluate the value of cancer-associated fibroblasts (CAFs) that positively express α-smooth muscle actin (α-SMA) and fibroblast activation protein (FAP) as survival indicators for patients with extrahepatic cholangiocarcinoma (eCCA). Methods The clinicopatholog...

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Bibliographic Details
Main Authors: Xiaojun Sui, Zhangqiang Zheng, Lei Yang, Dapeng Zhang, Xiangyu Sun, Ximo Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Diagnostic Pathology
Subjects:
Cancer-associated fibroblast
Cholangiocarcinoma
Alpha smooth muscle actin
Fibroblast activation protein
Prognosis
Online Access:https://doi.org/10.1186/s13000-025-01691-6
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