Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰
Trimethylpentyl polysilsesquioxane (POSS) gels containing kaolin and chitin promote clotting and stabilize and strengthen thrombi in vitro, and may offer a potential solution for treating non-compressible wounds. This study was designed to determine if the gels could stop bleeding in a junctional ar...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Biomaterials and Biosystems |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666534425000066 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849423068296904704 |
|---|---|
| author | Michelle A. Tucci Joseph D. Lichtenhan Hamad A. Benghuzzi Drew A. Hildebrandt |
| author_facet | Michelle A. Tucci Joseph D. Lichtenhan Hamad A. Benghuzzi Drew A. Hildebrandt |
| author_sort | Michelle A. Tucci |
| collection | DOAJ |
| description | Trimethylpentyl polysilsesquioxane (POSS) gels containing kaolin and chitin promote clotting and stabilize and strengthen thrombi in vitro, and may offer a potential solution for treating non-compressible wounds. This study was designed to determine if the gels could stop bleeding in a junctional arterial hemorrhage model. Anesthetized male swine were instrumented for systemic arterial pressure (MAP) measurement and saline infusion. A femoral artery was punctured (2 × 6 mm), allowed to bleed freely for 45 s, and then either QuikClot gauze bandage (QC; n = 7), POSS-Kaolin (PK) or POSS-Chitin (PC) (40 ml; n = 7/group) applied with no external compression. Blood loss (BL) at 60 min post-treatment was greater in QC (1166±79 ml) than PK (188±74 ml; p < 0.0001) or PC (523±116 ml; p = 0.0001); BL in PC was greater than in PK (p = 0.03). Total BL (180 min) was higher in QC (1210±93 ml) than PK (475±85 ml, p < 0.001) or PC (632±133 ml; p = 0.002) and in PC vs PK (p = 0.008). Time to clot was not different between PK (3 ± 1) or PC (10±3 min), but was longer in QC (44±9 min) than PK or PC (p < 0.0001 vs PK, p < 0.0003 vs PC). MAP fell 40±3 mmHg in QC by 10 min post-injury (p < 0.0003), and remained below control. PC MAP fell 41±5 mmHg, but returned to control, and MAP did not change in PK. POSS in combination with kaolin or chitin provided hemorrhage control and systemic hemodynamic stability without compression. These results support the treatment concept that this new approach to hemostasis can be efficacious in treating non-compressible trauma wounds. |
| format | Article |
| id | doaj-art-5fca4436d79e4564ba4c1c06ff89062a |
| institution | Kabale University |
| issn | 2666-5344 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomaterials and Biosystems |
| spelling | doaj-art-5fca4436d79e4564ba4c1c06ff89062a2025-08-20T03:30:48ZengElsevierBiomaterials and Biosystems2666-53442025-06-011810011110.1016/j.bbiosy.2025.100111Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰Michelle A. Tucci0Joseph D. Lichtenhan1Hamad A. Benghuzzi2Drew A. Hildebrandt3Anesthesiology, University of Mississippi Medical Center, 2500N. State Street, Jackson, MS, 39216, USA; Corresponding author.Hybrid Plastics, Inc., 55 WL Runnels Industrial Drive, Hattiesburg, MS, 39401, USABiology Department, Jackson State University, 1400J.R. Lynch Street, P.O. Box 18540, Jackson, MS, 39217, USASurgery, University of Mississippi Medical Center, 2500N. State Street, Jackson, MS, 39216, USATrimethylpentyl polysilsesquioxane (POSS) gels containing kaolin and chitin promote clotting and stabilize and strengthen thrombi in vitro, and may offer a potential solution for treating non-compressible wounds. This study was designed to determine if the gels could stop bleeding in a junctional arterial hemorrhage model. Anesthetized male swine were instrumented for systemic arterial pressure (MAP) measurement and saline infusion. A femoral artery was punctured (2 × 6 mm), allowed to bleed freely for 45 s, and then either QuikClot gauze bandage (QC; n = 7), POSS-Kaolin (PK) or POSS-Chitin (PC) (40 ml; n = 7/group) applied with no external compression. Blood loss (BL) at 60 min post-treatment was greater in QC (1166±79 ml) than PK (188±74 ml; p < 0.0001) or PC (523±116 ml; p = 0.0001); BL in PC was greater than in PK (p = 0.03). Total BL (180 min) was higher in QC (1210±93 ml) than PK (475±85 ml, p < 0.001) or PC (632±133 ml; p = 0.002) and in PC vs PK (p = 0.008). Time to clot was not different between PK (3 ± 1) or PC (10±3 min), but was longer in QC (44±9 min) than PK or PC (p < 0.0001 vs PK, p < 0.0003 vs PC). MAP fell 40±3 mmHg in QC by 10 min post-injury (p < 0.0003), and remained below control. PC MAP fell 41±5 mmHg, but returned to control, and MAP did not change in PK. POSS in combination with kaolin or chitin provided hemorrhage control and systemic hemodynamic stability without compression. These results support the treatment concept that this new approach to hemostasis can be efficacious in treating non-compressible trauma wounds.http://www.sciencedirect.com/science/article/pii/S2666534425000066Trimethylpentyl polysilsesquioxanePossHemostasisChitinKaolinNoncompressive |
| spellingShingle | Michelle A. Tucci Joseph D. Lichtenhan Hamad A. Benghuzzi Drew A. Hildebrandt Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰ Biomaterials and Biosystems Trimethylpentyl polysilsesquioxane Poss Hemostasis Chitin Kaolin Noncompressive |
| title | Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰ |
| title_full | Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰ |
| title_fullStr | Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰ |
| title_full_unstemmed | Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰ |
| title_short | Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰ |
| title_sort | arterial junctional hemostasis without compression evaluation of visco liquid hemostats in male swine✰ |
| topic | Trimethylpentyl polysilsesquioxane Poss Hemostasis Chitin Kaolin Noncompressive |
| url | http://www.sciencedirect.com/science/article/pii/S2666534425000066 |
| work_keys_str_mv | AT michelleatucci arterialjunctionalhemostasiswithoutcompressionevaluationofviscoliquidhemostatsinmaleswine AT josephdlichtenhan arterialjunctionalhemostasiswithoutcompressionevaluationofviscoliquidhemostatsinmaleswine AT hamadabenghuzzi arterialjunctionalhemostasiswithoutcompressionevaluationofviscoliquidhemostatsinmaleswine AT drewahildebrandt arterialjunctionalhemostasiswithoutcompressionevaluationofviscoliquidhemostatsinmaleswine |