Animal models for the assessment of hallucinations and their related biological mechanisms
Hallucinations represent a transdiagnostic phenomenon observed in multiple neuropsychiatric disorders, including schizophrenia, substance use disorder and substance-induced psychotic conditions. Despite their clinical prevalence, objective assessment remains challenging due to its subjective nature,...
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| Format: | Article |
| Language: | English |
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The Korean Society of Animal Reproduction and Biotechnology
2025-06-01
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| Series: | Journal of Animal Reproduction and Biotechnology |
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| Online Access: | https://www.e-jarb.org/journal/view.html?uid=2727&vmd=Full |
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| author | Gyebin Lee Sangmin Lee Yeung Bae Jin Han-Na Kim Joo Hyung Park Hye Jin Cha |
| author_facet | Gyebin Lee Sangmin Lee Yeung Bae Jin Han-Na Kim Joo Hyung Park Hye Jin Cha |
| author_sort | Gyebin Lee |
| collection | DOAJ |
| description | Hallucinations represent a transdiagnostic phenomenon observed in multiple neuropsychiatric disorders, including schizophrenia, substance use disorder and substance-induced psychotic conditions. Despite their clinical prevalence, objective assessment remains challenging due to its subjective nature, underscoring the critical need for validated translational models. The present study explores the biological mechanisms underlying hallucinations, evaluates the animal models developed to date, and discusses methods for analyzing these models along specific pathways. Hallucinations are primarily mediated through glutamatergic and/or serotonergic pathways. Numerous animal models for assessing hallucinations have been extensively reported; however, these models have mainly been designed to investigate specific neurotransmitter mechanisms, rather than encompassing all relevant pathways. Therefore, this study systematically examines currently established animal models based on the aforementioned neurotransmitter mechanisms and proposes future directions for developing universal animal models capable of comprehensively evaluating hallucinatory phenomena. The present study aims to provide deeper insights for future research involving animal models of hallucination. |
| format | Article |
| id | doaj-art-5fc40f2768614eae813261dda76a0669 |
| institution | Kabale University |
| issn | 2671-4639 2671-4663 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | The Korean Society of Animal Reproduction and Biotechnology |
| record_format | Article |
| series | Journal of Animal Reproduction and Biotechnology |
| spelling | doaj-art-5fc40f2768614eae813261dda76a06692025-08-20T03:28:43ZengThe Korean Society of Animal Reproduction and BiotechnologyJournal of Animal Reproduction and Biotechnology2671-46392671-46632025-06-01402768110.12750/JARB.40.2.76Animal models for the assessment of hallucinations and their related biological mechanismsGyebin Lee0https://orcid.org/0009-0002-2202-3193Sangmin Lee 1https://orcid.org/0009-0008-0541-468XYeung Bae Jin2https://orcid.org/0000-0001-6783-7970Han-Na Kim3https://orcid.org/0000-0002-0934-4411Joo Hyung Park4https://orcid.org/0009-0008-2089-1804Hye Jin Cha5https://orcid.org/0009-0002-9523-0759College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaCollege of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaCollege of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaCollege of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaCollege of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaCollege of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaHallucinations represent a transdiagnostic phenomenon observed in multiple neuropsychiatric disorders, including schizophrenia, substance use disorder and substance-induced psychotic conditions. Despite their clinical prevalence, objective assessment remains challenging due to its subjective nature, underscoring the critical need for validated translational models. The present study explores the biological mechanisms underlying hallucinations, evaluates the animal models developed to date, and discusses methods for analyzing these models along specific pathways. Hallucinations are primarily mediated through glutamatergic and/or serotonergic pathways. Numerous animal models for assessing hallucinations have been extensively reported; however, these models have mainly been designed to investigate specific neurotransmitter mechanisms, rather than encompassing all relevant pathways. Therefore, this study systematically examines currently established animal models based on the aforementioned neurotransmitter mechanisms and proposes future directions for developing universal animal models capable of comprehensively evaluating hallucinatory phenomena. The present study aims to provide deeper insights for future research involving animal models of hallucination.https://www.e-jarb.org/journal/view.html?uid=2727&vmd=Fullanimal modelhallucinationnmda receptorrepresentation-mediated learningserotonergic pathway |
| spellingShingle | Gyebin Lee Sangmin Lee Yeung Bae Jin Han-Na Kim Joo Hyung Park Hye Jin Cha Animal models for the assessment of hallucinations and their related biological mechanisms Journal of Animal Reproduction and Biotechnology animal model hallucination nmda receptor representation-mediated learning serotonergic pathway |
| title | Animal models for the assessment of hallucinations and their related biological mechanisms |
| title_full | Animal models for the assessment of hallucinations and their related biological mechanisms |
| title_fullStr | Animal models for the assessment of hallucinations and their related biological mechanisms |
| title_full_unstemmed | Animal models for the assessment of hallucinations and their related biological mechanisms |
| title_short | Animal models for the assessment of hallucinations and their related biological mechanisms |
| title_sort | animal models for the assessment of hallucinations and their related biological mechanisms |
| topic | animal model hallucination nmda receptor representation-mediated learning serotonergic pathway |
| url | https://www.e-jarb.org/journal/view.html?uid=2727&vmd=Full |
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