Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020)
Background: Cancer patients are at an increased risk for the incidence and complications of acute myocardial infarction (AMI) due to shared risk factors and treatment-related adverse effects. Mortality trends for AMI-related deaths in adult cancer patients in the U.S. remain unexplored. Methodology:...
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| Format: | Article |
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Elsevier
2025-03-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487525000091 |
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| author | Humza Saeed Uzair Majeed Minahil Iqbal Sufyan Shahid Anum Touseef Hussain Hammad Ahmad Iftikhar Momina Riaz Siddiqui Iftikhar Ali Ch Salman Khalid Naeem Khan Tahirkheli |
| author_facet | Humza Saeed Uzair Majeed Minahil Iqbal Sufyan Shahid Anum Touseef Hussain Hammad Ahmad Iftikhar Momina Riaz Siddiqui Iftikhar Ali Ch Salman Khalid Naeem Khan Tahirkheli |
| author_sort | Humza Saeed |
| collection | DOAJ |
| description | Background: Cancer patients are at an increased risk for the incidence and complications of acute myocardial infarction (AMI) due to shared risk factors and treatment-related adverse effects. Mortality trends for AMI-related deaths in adult cancer patients in the U.S. remain unexplored. Methodology: This study used CDC WONDER data for death certificates from 1999 to 2020, identifying U.S. adults (≥25 years) with cancer (ICD-10: C00-D49) who died of AMI (ICD-10: I21) as the underlying cause. Age-adjusted mortality rates (AAMRs) and annual percent changes (APCs) were calculated and stratified by gender, age, race, and geographic location. Results: Between 1999 and 2020, there were 109,462 AMI-related deaths in adult cancer patients. The AAMR decreased from 4.3 per 100,000 in 1999 to 1.4 in 2020. A significant decline occurred from 1999 to 2015 (APC: 6.65; 95 % CI: 6.95 to −6.40; p < 0.001), followed by a stable trend from 2015 to 2020 (APC: 1.36; 95 % CI: 2.69 to 0.91; p = 0.152). Men had higher AAMRs than women (3.5 vs. 1.5). AAMRs were highest in older adults (10.5) compared to middle-aged (0.7) and young adults (0.1). Racial disparities showed the highest AAMRs in non-Hispanic (NH) Black patients (2.7), followed by NH Whites (2.4), NH American Indian/Alaska Native (1.6), Hispanic/Latino (1.3), and NH Asian/Pacific Islander (1.1). Non-metropolitan areas had higher AAMRs than metropolitan areas (2.8 vs. 2.2). Conclusions: This analysis highlights a significant decline in AMI-related mortality among cancer patients in the U.S., with persistent disparities by gender, age, race and geographical location. |
| format | Article |
| id | doaj-art-5fc3d03d647f476d9f2a3bfd702308fb |
| institution | OA Journals |
| issn | 2772-4875 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj-art-5fc3d03d647f476d9f2a3bfd702308fb2025-08-20T01:57:19ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752025-03-012420037110.1016/j.ijcrp.2025.200371Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020)Humza Saeed0Uzair Majeed1Minahil Iqbal2Sufyan Shahid3Anum Touseef Hussain4Hammad Ahmad Iftikhar5Momina Riaz Siddiqui6Iftikhar Ali Ch7Salman Khalid8Naeem Khan Tahirkheli9Rawalpindi Medical University, Rawalpindi, Pakistan; Corresponding author.Allama Iqbal Medical College, Lahore, PakistanAllama Iqbal Medical College, Lahore, PakistanKhawaja Muhammad Safdar Medical College, Sialkot, PakistanCMH Lahore Medical College, Lahore, PakistanAllama Iqbal Medical College, Lahore, PakistanRawalpindi Medical University, Rawalpindi, PakistanSouth Oklahoma Heart Research, Oklahoma, United StatesOklahoma Heart Hospital, Oklahoma, United StatesOklahoma Heart Hospital, Oklahoma, United StatesBackground: Cancer patients are at an increased risk for the incidence and complications of acute myocardial infarction (AMI) due to shared risk factors and treatment-related adverse effects. Mortality trends for AMI-related deaths in adult cancer patients in the U.S. remain unexplored. Methodology: This study used CDC WONDER data for death certificates from 1999 to 2020, identifying U.S. adults (≥25 years) with cancer (ICD-10: C00-D49) who died of AMI (ICD-10: I21) as the underlying cause. Age-adjusted mortality rates (AAMRs) and annual percent changes (APCs) were calculated and stratified by gender, age, race, and geographic location. Results: Between 1999 and 2020, there were 109,462 AMI-related deaths in adult cancer patients. The AAMR decreased from 4.3 per 100,000 in 1999 to 1.4 in 2020. A significant decline occurred from 1999 to 2015 (APC: 6.65; 95 % CI: 6.95 to −6.40; p < 0.001), followed by a stable trend from 2015 to 2020 (APC: 1.36; 95 % CI: 2.69 to 0.91; p = 0.152). Men had higher AAMRs than women (3.5 vs. 1.5). AAMRs were highest in older adults (10.5) compared to middle-aged (0.7) and young adults (0.1). Racial disparities showed the highest AAMRs in non-Hispanic (NH) Black patients (2.7), followed by NH Whites (2.4), NH American Indian/Alaska Native (1.6), Hispanic/Latino (1.3), and NH Asian/Pacific Islander (1.1). Non-metropolitan areas had higher AAMRs than metropolitan areas (2.8 vs. 2.2). Conclusions: This analysis highlights a significant decline in AMI-related mortality among cancer patients in the U.S., with persistent disparities by gender, age, race and geographical location.http://www.sciencedirect.com/science/article/pii/S2772487525000091Acute myocardial infarctionCancerMortalityGender disparityRacial disparityEpidemiology |
| spellingShingle | Humza Saeed Uzair Majeed Minahil Iqbal Sufyan Shahid Anum Touseef Hussain Hammad Ahmad Iftikhar Momina Riaz Siddiqui Iftikhar Ali Ch Salman Khalid Naeem Khan Tahirkheli Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020) International Journal of Cardiology. Cardiovascular Risk and Prevention Acute myocardial infarction Cancer Mortality Gender disparity Racial disparity Epidemiology |
| title | Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020) |
| title_full | Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020) |
| title_fullStr | Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020) |
| title_full_unstemmed | Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020) |
| title_short | Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020) |
| title_sort | unraveling trends and disparities in acute myocardial infarction related mortality among adult cancer patients a nationwide cdc wonder analysis 1999 2020 |
| topic | Acute myocardial infarction Cancer Mortality Gender disparity Racial disparity Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2772487525000091 |
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